Late-Onset Seizures: Trial of Vascular Risk Investigation and Treatment

Launched by SAHLGRENSKA UNIVERSITY HOSPITAL · Aug 8, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether people who have their first seizure later in life—after age 50—should be checked for risks related to blood vessel problems, like those that can lead to stroke. Researchers want to see if identifying and managing these risks early can help prevent heart and brain-related health issues in the future. The study has two parts: one where participants get a detailed health check focused on blood vessel risks and follow-up care for one year, and another that looks at long-term health outcomes using health records from clinics.

People eligible for this study are adults aged 50 or older who have recently experienced their first unprovoked seizure or epilepsy diagnosis. To take part, they must be able to give consent and not have certain serious brain diseases or previous strokes. Participants can expect to undergo tests to check their heart and blood vessel health and receive advice or treatment to manage any risks found. This study is not yet recruiting, but it aims to improve care for older adults who experience seizures by better understanding how to protect their brain and heart health over time.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• Clinical study:
• • - First assessment for unprovoked seizures or epilepsy with onset after age 50 -- - vascular risk factor evaluation per the new routine at participating care givers
• Register study:
• • age ≥50 with a first-ever outpatient appointment to one of the participating clinics and
• • a first-listed diagnostic code for seizures or epilepsy (ICD-10: R568, G40)
• • Exclusion Criteria
• Clinical study:
• • Inability to consent.
• • Progressive brain disease (tumour or degenerative)
• Register study:
• • preexisting seizures/epilepsy, as demonstrated by a registered diagnostic code for seizures (ICD-10: R568, G40, G41) or a dispensed antiseizure medication (ATC-code: N03) more than 3 months before the initial consultation
• • a registered diagnostic code for stroke or TIA (ICD-10: I61, I63, I64, or G45 except G454) before the initial consultation, or
• • progressive brain disease, as indicated by diagnostic codes or drug prescriptions suggestive of brain tumors (ICD-10: C71, D33, D43, C793) or
• • neurocognitive disorders (ICD-10: F00-F03, F051, G30, G318, G912; ATC code: N06D).