PPI in Weaning Prediction

Launched by GAZIOSMANPASA RESEARCH AND EDUCATION HOSPITAL · Aug 6, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a way to help doctors decide when it’s safe to remove patients from mechanical breathing machines in the intensive care unit (ICU). Specifically, it looks at a measurement called the Peripheral Perfusion Index (PPI), which shows how well blood is flowing to the body’s extremities like the fingers. The study aims to see if PPI can better predict whether a patient will do well after the breathing tube is taken out, compared to current methods doctors use.

Patients who have been on a breathing machine for at least two days and are ready to try breathing on their own may be eligible to join. To participate, patients (or their legal representatives) need to agree to be part of the study. Those who are too unstable or have certain blood flow problems in their hands won’t be included. If you join this study, doctors will monitor your PPI along with other usual checks during the trial to help understand if this new measurement can improve the safety and timing of taking patients off ventilators.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients who have been on mechanical ventilation for at least 48 hours
• • Patients over 18 years of age who are planned to undergo extubation following a spontaneous breathing trial (SBT)
• • Patients or their legal representatives who provide informed consent to participate in the study
• Exclusion Criteria:
• • Patients for whom extubation is not planned due to hemodynamic instability
• • Patients with peripheral vascular disease or a history of hand surgery
• • Patients who die or cannot be followed up during the study period