Traditional Chinese Medicine Intervention for Ischemic Cerebrovascular Disease and Diabetes Mellitus: An Efficacy Comparative Study

Launched by GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE · Aug 12, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at whether long-term treatment using traditional Chinese medicine (TCM) can help people who have had a recent type of stroke called ischemic cerebral infarction and who also have diabetes. The study wants to see if TCM can improve patients’ brain function and their ability to take care of themselves over time. Participants will receive TCM treatments as part of their usual care and be checked at several points over a year to see how their recovery is going and how their quality of life changes.

To join this study, participants need to be adults who have had a stroke within the past 48 hours and have diabetes or meet the latest diabetes diagnosis criteria. They should have certain levels of stroke severity and meet specific TCM diagnosis guidelines. People will be followed up at 1 month, 3 months, 6 months, and 12 months after treatment starts to track their progress. This study is not yet recruiting, but it hopes to better understand how TCM might support recovery for stroke patients with diabetes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥ 18 years old, regardless of gender.
• 2. Previously diagnosed with diabetes, or with an unknown medical history, meeting the WHO 2023 diagnostic criteria for type 2 diabetes, including any of the following:
• • Fasting blood glucose ≥ 7.0 mmol/L.
• • 2-hour postprandial blood glucose ≥ 11.1 mmol/L.
• • Glycated hemoglobin ≥ 6.5%.
• 3. Acute cerebral infarction meets the diagnostic criteria of \*Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2023\*:
• • Acute onset.
• • Focal neurological deficits, with a few cases showing global neurological deficits.
• • The presence of a responsible lesion on imaging or symptoms/signs persisting for more than 24 hours.
• • Exclusion of non-vascular etiologies.
• • Exclusion of intracerebral hemorrhage by brain CT/MRI.
• • 4. Onset of cerebral infarction \< 48 hours.
• • 5. TCM syndrome conforms to the "toxin damaging brain collaterals" syndrome (referring to the diagnostic criteria (draft) of \*Research on the Diagnostic Criteria for the Syndrome of Mutual Binding of Stasis and Toxin in Ischemic Cardiovascular and Cerebrovascular Diseases\* (Ju Jianqing et al., 2023)).
• • 6. Modified Rankin Scale (mRS) before onset: 0 - 1 point.
• • 7. National Institutes of Health Stroke Scale (NIHSS) at admission: 4 - 24 points.
• • 8. Signed informed consent form.