Neural Contributions to Exercise-Induced Hypoalgesia With Blood Flow Restriction

Launched by UNIVERSITY OF GRAN ROSARIO · Aug 6, 2025

Keywords

ClinConnect Summary

This study is looking at how a type of exercise, combined with a special technique called blood flow restriction (BFR), affects the way the nervous system controls pain in healthy young adults. BFR involves gently limiting blood flow to the muscles while doing low-intensity resistance exercises, which might change how sensitive you are to pain. Researchers will measure pain sensitivity before and after the exercise using safe, non-invasive tests to better understand how this method might help reduce pain.

If you are healthy, without any current pain or certain medical conditions like heart problems, diabetes, or recent surgery, and you haven’t tried BFR training before, you might be able to take part. Participants will attend just one session at the research center, where they will do the exercise with BFR while researchers perform simple tests to check pain sensitivity. This study could help improve future treatments for pain and rehabilitation by showing how the nervous system responds to this type of exercise.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Asymptomatic at the time of evaluation.
• • Able to provide written informed consent.
• • Available to attend a single evaluation and intervention session at the research center.
• Exclusion Criteria:
• • Bilateral knee symptoms or suspected patellar tendinopathy.
• • Increased symptoms with dynamic loading.
• • Neurological disorders.
• • Inflammatory rheumatic diseases.
• • Cardiac diseases.
• • Any surgery within the last 3 months.
• • Pregnancy.
• • Alcohol consumption on the day of participation.
• • Hypertension (systolic blood pressure ≥140 mmHg).
• • History of deep vein thrombosis.
• • History of endothelial dysfunction.
• • Peripheral vascular disease.
• • Diabetes.
• • Active infection.
• • Spinal or referred pain.
• • Previous experience with blood flow restriction (BFR) training.
• • Overweight or obesity.