Predictive Factors for Initial MMSE Score and Rapid Decline in Alzheimer's Disease Patients

Launched by CENTRE HOSPITALIER DE GONESSE · Aug 8, 2025

Keywords

ClinConnect Summary

This study is looking at people with Alzheimer’s disease to understand what affects their thinking and memory scores when they first come to the clinic, and what might predict a faster decline over one year. Researchers will review past medical records from patients seen at the Memory Clinic of Gonesse Hospital. They will look at factors like age, education, medical history, nutrition, mood, and how much stress their caregivers experience. The goal is to learn more about what influences early memory and thinking abilities and how quickly these skills change, which could help doctors provide better care and support for patients and families.

To be part of this study, patients need to have a confirmed diagnosis of Alzheimer’s disease and have had at least two memory tests (called MMSE) done 12 months apart at the Memory Clinic of Gonesse. People with other types of brain diseases or those who have moved away from the clinic’s area cannot join. Since this study uses existing medical records, participants won’t need to attend extra visits but will help improve understanding of Alzheimer’s disease progression. This research is not yet recruiting patients but hopes to offer valuable insights for planning care in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Confirmed diagnosis of Alzheimer's disease according to NIAA 2018 or IWG 2021 criteria
• • At least two MMSE evaluations spaced 12 months apart
• • Follow-up at the Memory Clinic of CH Gonesse
• Exclusion Criteria:
• • Presence of other neurodegenerative diseases (e.g., Frontotemporal Dementia, Multiple System Atrophy, Vascular Dementia, LATE)
• • Patient has moved out of the study area (outside the CH Gonesse territory)