Relationship Between Central Sensitization Levels and Treatment Outcomes in Frozen Shoulder Treatment

Launched by SULTAN 1. MURAT STATE HOSPITAL · Aug 9, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how different levels of a condition called central sensitization might affect the results of treatment for frozen shoulder. Frozen shoulder is a condition that causes pain and stiffness in the shoulder, making it hard to move. The study focuses on patients who receive a special injection directly into the shoulder joint to help relieve pain and improve movement. Researchers want to understand if people with higher sensitivity to pain respond differently to this treatment compared to those with lower sensitivity.

To take part in the study, participants need to be between 18 and 75 years old and have had shoulder pain and limited movement for 3 to 12 months. Their shoulder movement must be significantly reduced in at least two directions. People with pain in both shoulders, certain other health conditions, recent shoulder treatments, or specific shoulder injuries won’t be eligible. If you join the trial, you can expect to receive an injection in your shoulder and have your pain levels and movement monitored to see how well the treatment works. This study is currently looking for participants to help better understand who benefits most from this type of treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Being between 18 and 75 years of age
• • More than one-third of the active and passive movement of the painful shoulder is limited in two or more planes
• • Having pain and limited movement in the shoulder for 3-12 months
• Exclusion Criteria:
• • Having bilateral shoulder pain
• • Patients with incomplete study data
• • Having cervical radiculopathy
• • Having a predominant central sensitization syndrome (such as fibromyalgia, chronic fatigue syndrome)
• • Patients taking antidepressants or anticonvulsants that may affect central sensitization
• • Having a history of rheumatological disease
• • Having a history of active malignancy
• • Patients receiving treatment for active psychiatric disorders
• • Having a history of trauma and/or surgery in the same shoulder region
• • Patients who received local shoulder injections and/or physical therapy within the last 3 months
• • Patients with calcific tendonitis, glenohumeral osteoarthritis, or acromioclavicular joint osteoarthritis on plain radiographs
• • Having a full-thickness rotator cuff tear on shoulder ultrasound