Efficacy of Bioactive Glass vs. Xenograft in Maxillary Sinus Augmentation

Launched by SUEZ CANAL UNIVERSITY · Aug 14, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two different materials used to help rebuild bone in the upper jaw (specifically, the area under the sinus) for people who need dental implants but have lost bone in that region. The researchers want to see how well a new material called bioactive glass works compared to a more traditional material made from animal bone (called a xenograft). They will look at the amount of new bone grown and how healthy it is, using special imaging scans and, if possible, tissue samples.

People who might join this study are adults between 20 and 65 years old who need bone added to their upper jaw because they don’t have enough bone to support dental implants. To qualify, they should be generally healthy, have limited bone height in the back of the upper jaw, and be able to attend follow-up visits. The study will not include people with certain health issues that affect bone healing, heavy smokers, those with active sinus problems, or women who are pregnant or breastfeeding. Participants will be randomly assigned to receive either the bioactive glass or the traditional bone graft during their sinus surgery, and their bone growth will be monitored over time using detailed scans. This research is taking place at the Faculty of Dentistry, Suez Canal University, and is not yet open for enrollment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients requiring maxillary sinus floor augmentation for dental implant placement.
• • Residual alveolar bone height ≤ 4 mm in posterior maxilla (SA4 classification).
• • Age between 20 to 65 years.
• • Good general health and able to attend scheduled follow-up visits.
• • Signed written informed consent.
• Exclusion Criteria:
• • Presence of systemic conditions that could affect bone healing (e.g., uncontrolled diabetes, osteoporosis).
• • History of radiotherapy in the head and neck region.
• • Heavy smoking (more than 10 cigarettes/day).
• • Active sinus pathology or previous sinus surgery.
• • Pregnant or breastfeeding women.
• • Use of medications affecting bone metabolism (e.g., bisphosphonates or corticosteroids).
• • Poor oral hygiene or untreated periodontal disease.