Study on the Mechanism of Zuoqing San Promoting Postoperative Wound Healing of Anal Fistula by Inhibiting ROS-dependent NETosis
Launched by THE SECOND AFFILIATED HOSPITAL OF ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE · Aug 18, 2025
Trial Information
Current as of August 23, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
A total of 60 patients who underwent anal fistula surgery at the Second Affiliated Hospital of Anhui University of Chinese Medicine from September 2024 to March 2025 were included. They were randomly divided into the experimental group (treated with Left Qing San fumigation and washing) and the control group (treated with placebo fumigation and washing) at a ratio of 1:1.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Recurrent swelling and pain, along with pus discharge around the anus;
- • Preoperative MRI or ultrasound confirmed the presence of the fistula;
- • Underwent incision of the anal fistula, with the postoperative wound diameter ranging from 2 to 4 cm.
- Exclusion Criteria:
- • 1. Inflammatory bowel disease (such as Crohn's disease) related anal fistula;
- • 2. Complicated with severe dysfunction of heart, liver and kidney (ALT/AST \> 2 times upper limit, Cr \> 1.5 mg/dL);
- • 3. Pregnant or lactating women;
- • 4. Those who are known to be allergic to the components of Zuoqing San;
About The Second Affiliated Hospital Of Anhui University Of Traditional Chinese Medicine
The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine is a leading clinical research institution dedicated to advancing the field of traditional Chinese medicine through rigorous scientific investigation. As a prominent teaching hospital, it integrates clinical practice with education and research, fostering innovation in therapeutic approaches and healthcare delivery. The hospital is committed to conducting high-quality clinical trials that adhere to ethical standards and regulatory guidelines, aiming to improve patient outcomes and contribute to the global understanding of traditional medicine methodologies. Its multidisciplinary team of experts collaborates closely with academic and healthcare partners to ensure the successful implementation and dissemination of research findings.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Hefei, Anhui, China
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported