Impact of Aortic Geometry on Vascular Remodeling After Stent Implantation in Coarctation of the Aorta

Launched by ASSIUT UNIVERSITY · Aug 12, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how the shape and structure of the aorta—the main blood vessel leaving the heart—change after placing a small tube called a stent in people with a condition called coarctation of the aorta. This condition causes a narrowing of the aorta, which can lead to high blood pressure and other heart problems. The study aims to understand how changes in the aorta’s shape relate to blood pressure and heart health, and how these changes differ between people who have had this narrowing repaired and those with healthy aortas.

People who are 12 years or older, weigh at least 20 kilograms (about 44 pounds), and have been diagnosed with coarctation of the aorta may be eligible, especially if they have a certain level of pressure difference across the narrowed area that is measured during a heart procedure. Participants will need to have had special imaging tests (like CT scans) before and after stent placement so researchers can compare the aorta’s shape over time. The study does not include people with certain other heart problems or genetic conditions. If you join, you can expect your doctors to review your heart images and health information to help understand how the stent affects your aorta and overall heart health. This study is not yet recruiting participants but aims to improve care for people with this condition in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 12 years.
• • Diagnosed with native or recurrent coarctation of the aorta.
• • Transcatheter systolic pressure gradient ≥ 20 mmHg.
• • Body weight ≥ 20 kg.
• • Availability of pre- and post-stenting CT aortography data.
• Exclusion Criteria:
• • Patients with obstructive lesion of LVOT or aortic valve dysfunction greater than moderate (requiring surgical intervention)..
• • Patients with other causes of secondary hypertension.
• • Associated complex congenital heart defects (aside from simple septal defects and patent ductus arteriosus)
• • Genetic syndromes
• • Connective tissue disorder
• • History of surgery involving the aortic root or ascending aorta.
• • Incomplete imaging or missing data relevant to the study.