High Flow Nasal Cannula Versus High Velocity Nasal Insufflation for Weaning

Launched by ASSIUT UNIVERSITY · Aug 20, 2025

Keywords

ClinConnect Summary

This clinical trial is comparing two types of oxygen therapy to help patients who are coming off a breathing machine (ventilator) after being critically ill. When patients are ready to have the breathing tube removed, some still struggle and need the tube put back in, which can be dangerous. The study is looking at whether a newer method called high-velocity nasal insufflation, which delivers oxygen at a faster speed through small nasal tubes, works better than the more common high-flow nasal cannula in preventing breathing problems after the tube is taken out.

Adults who have been on a ventilator for more than a day due to breathing failure and are considered at high risk of having trouble after the tube is removed may be eligible to join. To participate, patients need to be stable enough to try breathing on their own and meet certain health criteria. Those with certain brain injuries, previous tracheotomy, or severe organ failure are not eligible. If you join the study, you can expect to receive one of the two oxygen treatments after the breathing tube is removed, and the medical team will monitor how well you breathe and whether you need the tube reinserted. This trial hopes to find the best way to support patients during this critical time and reduce the chances of needing to go back on the ventilator.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults (≥18 years) intubated for \>24 hours due to acute respiratory failure, identified as high-risk for extubation failure AND fulfilling standard readiness-to-wean criteria (e.g., resolution of cause of intubation, adequate gas exchange \[P/F ≥150\], hemodynamic stability, spontaneous breathing trial \[SBT\] success)
• Exclusion Criteria:
• • Patients with central nervous system disorders unrelated to hypercapnic encephalopathy or hypoxemia.
• • Patients with post arrest encephalopathy.
• • Patient with previous tracheotomy.
• • Patients who received noninvasive ventilation without subsequent intubation.
• • Patients with end organ failure.