Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE · Aug 14, 2025

Keywords

ClinConnect Summary

This study is looking at how well adults with certain neurological or metabolic conditions—like muscle diseases, obesity, or nerve disorders—can move, especially when walking and using their arms. Researchers in Belgium will use a special wearable device called Syde® to track participants’ movements in their daily lives for up to two years. The goal is to better understand how these conditions affect movement over time and to find reliable ways to measure changes in walking speed and mobility that can help with future treatments.

To take part, adults need to be able to walk at least 10 meters on their own and have a confirmed diagnosis of one of the specific conditions, such as myotonic dystrophy, Charcot-Marie-Tooth disease, myasthenia gravis, or obesity with a body mass index of 35 or higher. Participants will be asked to wear the device and follow study procedures, but there are no treatments or surgeries involved. People who can’t walk, have serious memory or understanding problems, recent injuries, or are pregnant cannot join. This study is currently enrolling participants and aims to include about 300 people to learn more about how these diseases affect everyday movement.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Ambulant patients (i.e. able to walk 10 meters without assistance)
• • Confirmed diagnosis by the investigator based on current gold standard in his/her disease (genetic testing, clinical criteria, etc.)
• • Myotonic dystrophy type 1 (DM1) and Charcot-Marie-Tooth (CMT) patients should present sensitive of motor signs on physical examination.
• • Myasthenic patients should be seropositive, and Myasthenia Gravis Foundation of America (MGFA) class II to IV.
• • Patient with morbid obesity (Body Mass Index\> or = 35 at inclusion visit).
• • Signed informed consent form by patient him/herself and patient willing and able to comply with all study procedures.
• Exclusion Criteria:
• • Non-ambulant patients
• • Patients with extreme cognitive disorders that limit their understanding of the exercises to be performed
• • Patients who have undergone a surgical procedure or who have experienced recent trauma (within fewer than 6 months) affecting the upper or lower limbs
• • A concomitant chronic or acute neurological, endocrine, infectious, allergic, or inflammatory pathology within the 3-week period immediately prior to inclusion
• • Patients who are participating in an interventional clinical trial
• • Pregnant or breastfeeding women