Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.

Launched by WALTER REED NATIONAL MILITARY MEDICAL CENTER ·

Keywords

ClinConnect Summary

This clinical trial is studying how different steroid medicines added to a standard pain injection during total knee replacement surgery affect pain relief, opioid use, and recovery. The goal is to find out if adding a steroid helps control pain better and reduces the need for opioid painkillers after surgery. The trial will also compare a newer extended-release steroid called Zilretta to a traditional steroid, methylprednisolone, to see which one works best and is safer—especially for people with diabetes or prediabetes.

Adults aged 65 to 74 who are having total knee replacement surgery for severe knee arthritis or injury may be eligible to join. During surgery, participants will be randomly assigned to get either the standard pain injection alone, the injection plus methylprednisolone, or the injection plus Zilretta. Those with diabetes or prediabetes will only receive the standard injection or Zilretta to help researchers study safety for blood sugar control. After surgery, participants will be followed to track their pain levels, use of opioid pain medicine, knee movement, and overall recovery, including whether additional procedures are needed if the knee becomes stiff. Patients will also share their own experiences with pain and knee function through surveys.

Gender

ALL

Eligibility criteria