Botensilimab + Balstilimab vs Best Supportive Care as Therapy in Chemo-refractory, Unresectable, Colorectal Adenocarcinoma
Launched by CANADIAN CANCER TRIALS GROUP ·
Trial Information
Current as of September 29, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is studying whether a new treatment using two immunotherapy drugs, botensilimab and balstilimab, can help people with colorectal cancer that cannot be removed by surgery and has not responded to chemotherapy. The main goal is to find out if these drugs can help patients live longer. The study will also look at whether the treatment can improve quality of life, slow down or shrink tumors, and identify any signs in the tumor or blood that might predict who benefits the most. Researchers will also carefully check the safety of these drugs and how the body processes them.
The trial is open to adults aged 65 to 74 with colorectal cancer that cannot be removed by surgery and who have already tried chemotherapy without success. People of all genders may participate. If you join, you might receive the new immunotherapy treatment or the best supportive care, which focuses on managing symptoms and improving comfort. The study is not yet recruiting participants, but it aims to offer a new option for those with limited treatments available.
Gender
ALL
Eligibility criteria
About Canadian Cancer Trials Group
The Canadian Cancer Trials Group (CCTG) is a leading clinical research organization dedicated to advancing cancer treatment through innovative clinical trials. Based at Queen’s University in Kingston, Ontario, CCTG collaborates with a network of healthcare professionals, institutions, and patients across Canada to design and implement trials that evaluate new therapies, improve patient outcomes, and enhance the understanding of cancer biology. Committed to excellence in research, CCTG fosters a multidisciplinary approach, engaging experts in various fields to ensure rigorous methodologies and ethical standards. By prioritizing patient-centered care and accessibility, CCTG plays a pivotal role in shaping the future of cancer care in Canada and beyond.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Trial Officials
Jonathan Loree
Study Chair
BCCA-Vancouver Cancer Centre
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported