Fecal Microbiota Transplantation in Patients With Ulcerative Colitis

Launched by SEOUL NATIONAL UNIVERSITY HOSPITAL ·

Keywords

ClinConnect Summary

This study is testing whether fecal microbiota transplantation (FMT), which means giving healthy gut bacteria from donor stool to a person with ulcerative colitis (UC), can help. It is an interventional, single-group trial (no control group) happening at several hospitals in Korea. About 30 people aged 10–80 with mild-to-moderate UC will receive FMT at weeks 0 and 4, delivered either during a colonoscopy/sigmoidoscopy or as about four oral capsules. Researchers will look mainly at whether participants can stop steroids and improve by week 12, and they will also check long-term safety and effects up to week 48.

To join, you would need to be 10–80 years old, have UC for at least 3 months, and have mild-to-moderate disease with rectal involvement of at least 5 cm (Mayo score 4–10, or partial Mayo 2–7). You must not have severe UC requiring hospitalization, certain infections, recent antibiotics, or recent/planned use of some immune therapies, among other safety rules. If you participate, you’ll have visits and tests to track symptoms, colon health, and lab markers, plus research on changes in gut bacteria and related biology. The trial is currently enrolling by invitation, results aren’t posted yet, and the study is expected to finish around June 2027.

Gender

ALL

Eligibility criteria