Umbilical Hernia RCT-Absorbable vs. Permanent Suture

Launched by UNIVERSITY OF BRITISH COLUMBIA ·

Keywords

ClinConnect Summary

This trial, called PAPYRUS, is studying whether using a slowly dissolving (absorbable) suture called polydioxanone is as good as a traditional permanent suture called polypropylene when repairing small umbilical hernias (defect 2 cm or smaller). It’s a Canada-wide, multi-center study that randomly assigns adults undergoing elective open repair to receive one of the two sutures, with participants unaware which one they received. The main question is whether the absorbable suture is not worse than the permanent one for preventing the hernia from coming back over 24 months. The study will also look at short-term and longer-term problems after surgery and how the repair affects quality of life.

To be eligible, people must be 18 or older and have a primary (not recurrent) umbilical hernia with a defect of 2 cm or less, planned for elective open repair. Exclusions include larger or multiple defects, prior repair in the area, pregnancy, infection, obesity (BMI 35 or higher), certain health conditions, or other factors the surgeon believes make repair unsuitable. If enrolled, you’ll have standard surgery and be followed up at about 30 days, 12 months, and 24 months to check for recurrence, complications, and how you feel overall. Recruitment is planned to start in 2026, with results expected around 2030, and findings will help guide future guidelines on which suture type to use for this common procedure.

Gender

ALL

Eligibility criteria