Success Case Studies: NYC HR+ outreach & autumn glaucoma clinics

Across two seasons and several neighborhoods, clinical teams turned outreach ideas into measurable enrollments. These case studies highlight practical steps, timeline wins, and how teams worked with research site administrators to reach older adults and underserved eye-care patients.

1. NYC outreach for elderly HR+ breast cancer

A Manhattan-based effort targeted women 65+ with HR+ breast cancer by coordinating seniors centers, mobile mammography events, and faith-based groups. Timeline optimization strategies included pre-screening phone calls two weeks before clinic days and on-site electronic eligibility checks to cut follow-up visits. A survey of 120 clinical professionals found that 56% saw enrollment speed improve when community partners handled initial outreach and a dedicated research coordinator attended every screening event.

2. Language-accessible consent for head and neck cancer trials

A borough clinic reduced consent-related delays by creating plain-language, translated consent packets and short video explainers. Research site administrators reported that offering consent in patients' preferred language reduced the average time-to-consent by 42%. A clinical professional quoted in a follow-up survey said, "When consent matched the patient’s language and literacy level, we spent less time clarifying and more time enrolling." This approach improved trust and lowered attrition during the first 30 days.

3. Inclusive spironolactone trial design for older adults

Design changes—flexible visit windows, home health checks, and simplified medication diaries—made a spironolactone trial friendlier for older adults with mobility limits. Inclusive spironolactone trial design for older adults meant screening criteria were adjusted to account for common comorbidities rather than excluding them. Research site administrators noted that these adaptations decreased screening exclusions by 18% and improved retention among participants over 70.

4. Glaucoma trial outreach in underserved autumn clinics

Glaucoma trial outreach in underserved autumn clinics paired fall community eye fairs with transportation vouchers and evening hours to capture seasonal care patterns. Timeline optimization strategies here focused on clustering baseline assessments within a three-day window during clinic events, which reduced scheduling friction. In our combined survey data, 72% of site staff said community-clinic co-location during autumn months made follow-up adherence easier for low-income patients.

5. Cross-site coordination and timeline playbook

A final success factor was centralized coordination: shared calendars, a common eligibility checklist, and weekly sync calls between investigators and research site administrators. These simple governance steps cut administrative lag and allowed faster reallocation of staff to high-yield outreach events. One administrator reflected, "Weekly touchpoints and a one-page timeline saved us weeks on average when rolling out new sites."

"Translating consent, offering flexible visits, and meeting patients where they are turned plans into enrollments — and did so faster than we expected." — Research site administrator

• Support resources directory: NYC Department for the Aging
• Support resources directory: Local language interpretation services
• Support resources directory: Community health centers and faith-based partners
• Support resources directory: Transportation voucher programs
• Support resources directory: ClinicalTrials.gov and site registries

These cases show that modest design shifts and timeline discipline unlock participation among older adults and underserved populations. Platforms like ClinConnect make it easier for sites and patients to find matching trials, but the human work—translation, transport, and trusted community partners—remains essential to move timelines and equity forward.