Autoimmunity in Inner Ear Disease

Launched by NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS (NIDCD) · Nov 2, 1999

Keywords

ClinConnect Summary

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Have sensorineural (nerve/inner ear) hearing loss of at least 30 dB in each ear, which has rapidly progressed.
• • Are in good general health.
• • Are sterile or use contraception (if a woman of child-bearing age).
• • Are able to speak and understand English or Spanish.
• Exclusion Criteria:
• • Have had any previous reaction to prednisone, or history of psychiatric reaction to corticosteroids.
• • Have used corticosteroids for more than 30 days within the past 90 days. Patients who have been off corticosteroids for at least 30 days may be eligible.
• • Have any significant heart, lung, digestive, blood, or neurologic disorders.
• • Have tuberculosis (TB), brittle or unstable insulin-dependent diabetes mellitus, active malignancy or prior chemotherapy, pancreatitis, active peptic ulcer disease, kidney failure, history of shingles, or known (other) autoimmune disease.
• • Have had a positive test for HIV, hepatitis C or B.
• • Have any type of middle ear disorder.
• • Are breast-feeding or pregnant.

Trial Officials