Search / Trial NCT00000375

Continuation Electroconvulsive Therapy Vs Medication to Prevent Relapses in Patients With Major Depressive Disorder

Launched by NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH) · Nov 2, 1999

Trial Information

Current as of December 09, 2024

Completed

Keywords

Adult Antidepressive Agents Depressive Disorder Electroconvulsive Therapy Female Human Lithium Male Nortriptyline Serotonin Uptake Inhibitors Antidepressive Agents *Therapeutic Use Antidepressive Agents Adverse Effects Lithium *Therapeutic Use Lithium Adverse Effects Nortriptyline *Therapeutic Use Nortriptyline Adverse Effects

ClinConnect Summary

To define the role of continuation electroconvulsive therapy (C-ECT) in relapse-prevention of seriously ill patients with major depressive disorder (MDD). To determine the relative efficacy and safety of C-ECT in comparison to the traditional approach of continuation pharmacotherapy (C-PHARM) to prevent relapses of MDD.

Electroconvulsive therapy (ECT) is a highly effective treatment for MDD that is helpful for patients with the most severe forms of affective illness; however, relapse after successful acute phase ECT or pharmacotherapy remains a major public health problem. To prevent relap...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • -
  • Patients must have:
  • Major depressive disorder that is responsive to acute phase ECT.

Trial Officials

Charles Kellner, MD

Study Chair

Mustafa Husain, MD

Principal Investigator

Teresa Rummans, MD

Principal Investigator

George Petrides

Principal Investigator

About National Institute Of Mental Health (Nimh)

The National Institute of Mental Health (NIMH) is a leading federal agency dedicated to advancing the understanding and treatment of mental health disorders through innovative research and clinical trials. As part of the National Institutes of Health (NIH), NIMH focuses on a broad spectrum of mental health issues, including mood disorders, anxiety disorders, schizophrenia, and developmental disorders. By fostering collaboration among researchers, clinicians, and the community, NIMH aims to translate scientific discoveries into effective interventions and improve mental health outcomes for individuals across the lifespan. Through its commitment to rigorous research methodologies and ethical standards, NIMH plays a pivotal role in shaping the future of mental health care and policy.

Locations

Newark, New Jersey, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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