Toward Better Outcomes in Osteoarthritis
Launched by STANFORD UNIVERSITY · Nov 3, 1999
Trial Information
Current as of March 23, 2025
Completed
Keywords
ClinConnect Summary
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most popular agents used to treat the joint pain and inflammation associated with OA. Although NSAIDs are useful for pain management, recent studies have not found NSAIDs to be better than acetaminophen for the treatment of painful knee OA. The relative lack of efficacy and possibility of accelerated disease progression, coupled with the known gastrointestinal risks of these medications, especially to the elderly, have led us to reevaluate NSAIDs as the first-line medical therapy for osteoarthritis. Our dominant NSAID-based approach to t...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Knee osteoarthritis
- • Moderate radiographic evidence by Kellgren and Lawrence grade 2-4
- • Knee pain \> 20 on VAS pain scale
- Exclusion Criteria:
- • Bilateral knee replacements
- • Unwillingness to take acetaminophen for pain relief
Trial Officials
Nancy Lane, MD
Study Director
UCSF, Division of Rheumatology, SFGH
About Stanford University
Stanford University is a prestigious academic institution renowned for its cutting-edge research and innovation in healthcare and medicine. As a clinical trial sponsor, Stanford leverages its extensive resources, including a collaborative network of world-class researchers and state-of-the-art facilities, to advance medical knowledge and improve patient care. The university is committed to conducting rigorous, ethical research that adheres to the highest standards of scientific integrity, fostering an environment where groundbreaking discoveries can translate into effective clinical applications. Through its clinical trials, Stanford aims to address critical health challenges and contribute to the development of novel therapies and treatment strategies.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
San Francisco, California, United States
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0
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