Naltrexone for Relapse Prevention

Launched by UCONN HEALTH · Nov 2, 1999

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Gender

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Eligibility criteria

• Inclusion Criteria:
• • Meets criteria for alcohol dependence.
• • Abstinent from alcohol for a period of at least 3 days prior to beginning of study.
• • Able to read English and complete study evaluations.
• • Females who are postmenopausal, have had surgical sterilization, or use reliable means of birth control.
• Exclusion Criteria:
• • Meets criteria for dependence on a psychoactive substance other than alcohol and nicotine and/or cannabis.
• • Prior history of opioid dependence.
• • Regular use of psychoactive drugs including anxiolytics and antidepressants.
• • Prior treatment with naltrexone.
• • Current use of disulfiram.
• • Psychotic or otherwise severely psychiatrically disabled (e.g., suicidal, current mania).
• • Significant underlying medical conditions such as hepatic, cerebral, renal, thyroid, or cardiac disease.
• • Abstinent longer than 28 days prior to randomization.