Naltrexone Treatment of Alcohol Dependence

Launched by NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM (NIAAA) · Nov 2, 1999

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Gender

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Eligibility criteria

• Inclusion Criteria:
• • Meets criteria for current diagnosis of alcohol dependence.
• • Subjects used more than 15 standard alcohol drinks (average)/week with at least 1 day of 5 or more drinks in the past 30 days.
• • Successful completion of medical detoxification.
• • Lives within a commutable distance to the Treatment Research Center and agrees to follow-up visits.
• • Understands and signs the informed consent.
• Exclusion Criteria:
• • Current diagnosis of any substance dependence other than alcohol, nicotine, or marijuana.
• • Evidence of opiate use in the past 30 days.
• • Current treatment with psychotropic medications, including disulfiram (Antabuse) (excluding short-term use of benzodiazepines for detoxification).
• • History of unstable or serious medical illness, including need for opioid analgesics.
• • Severe physical or medical illnesses such as AIDS, active hepatitis, significant hepatocellular injury as evidenced by elevated bilirubin levels, and current severe psychiatric symptoms.
• • Use of an investigation medication in the past 30 days.
• • Female subjects who are pregnant, nursing, or not using reliable method of contraception.