Sertraline and Cognitive Therapy in Depressed Alcoholics

Launched by NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM (NIAAA) · Nov 2, 1999

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Eligibility criteria

• Inclusion Criteria:
• • Meets criteria for major depressive episode.
• • Meets criteria for alcohol abuse or dependence thirty days prior to entering the study.
• • Has had no more than one previous inpatient medical detoxification.
• • Able to maintain sobriety for ten days.
• • Able to read and understand questionnaires and informed consent.
• • Lives within 50 miles of the study site, has a stable living situation, and a reliable source of collateral reporting.
• Exclusion Criteria:
• • Meets criteria for any other psychoactive substance dependence other than nicotine.
• • Any psychoactive substance abuse (other than nicotine or marijuana) within 30 days before beginning of study.
• • Meets criteria for other psychiatric disorders including: panic disorder, obsessive-compulsive disorder, bipolar affective disorder, cyclothymia, schizophrenia, any organic mental disorder, eating disorder, dissociative disorder, or post-traumatic stress disorder.
• • Has evidence of treatment resistant depression defined as more than one previous treatment episode for depression, which can include hospitalization and/or one course of antidepressant medication.
• • Patients may not have been prescribed a specific serotonergic medication within the month prior to study and may not have taken any antidepressant or antipsychotic within the two weeks prior to study.
• • Current use of disulfiram (Antabuse) or anti-seizure medications.
• • Clinically significant medical problems: cardiovascular, renal, gastrointestinal, or endocrine problems that would limit participation or limit medication ingestion.
• • Hepatocellular disease.
• • Females who are pregnant, nursing, or not using a reliable form of birth control.
• • Current charges pending for violent crime (excluding DUI related offenses).
• • Previous adverse experience with a serotonin reuptake inhibitor.
• • Current homicidal or suicidal ideation.