Childhood Asthma Management Program (CAMP) Phases I (Trial), II (CAMPCS), III (CAMPCS/2), and IV (CAMPCS/3)
Launched by JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH · Oct 27, 1999
Trial Information
Current as of May 09, 2025
Completed
Keywords
ClinConnect Summary
BACKGROUND:
Asthma is a serious chronic condition, affecting approximately 14 million Americans. People with asthma experience well over 100 million days of restricted activity annually, and costs for asthma care exceed $10 billion a year. Asthma is much more prevalent among children than adults.
Hospitalizations for asthma have been increasing among children. For example, from 1979 to 1987, the hospital discharge rate with asthma as the first-listed diagnosis rose 43 percent among children less than 15 years of age, from 19.8 to 28.4 discharges per 10,000 population.
Death rates for ast...
Gender
ALL
Eligibility criteria
- Inclusion criteria:
- • Age 5 to 12 years at time of screening
- * Chronic asthma as evidenced by one or more of the following historical findings for at least 6 months during the past year:
- • Asthma symptoms at least 2 times per week
- • 2 or more usages per week of an inhaled bronchodilator
- • Daily asthma medication
- • Current asthma symptoms either by diary symptom code of 1 or greater or am or pm PEFR less than 80% of personal best post-bronchodilator value by diary, on 8 or more days during the prn screening period
- • Methacholine sensitivity: estimated PC20 FEV1 less than or equal to 12.5 mg/ml
- • Consent of guardian and assent of child
- • Ability to comply with trial for 5 - 6.5 years
- Exclusion criteria:
- * Presence of one or more of the following confounding or complicating problems:
- • Any other active pulmonary disease
- • Any chronic condition presumed to interfere with the successful completion of the project or confound its interpretation
- • Pulmonary function testing findings suggesting a ventilatory defect other than asthma, or evidence of existing irreversible lung damage
- • Severe chronic sinusitis or nasal polyposis
- • Introduction of or a change in allergen immunotherapy within the past month
- • Use of more than 4 sprays of nasal steroids daily (only beclomethasone allowed)
- • Pregnancy
- • Current use of metoclopramide, ranitidine, or cimetidine
- • Treatment for gastroesophageal reflux
- • Participation in another drug study
- * Evidence of severe asthma as indicated by one or more of the following:
- • Two or more hospitalizations for asthma in the past year
- • Six or more steroid bursts in the past year
- • Demonstrated need for continuous use of glucocorticoids, either oral or inhaled
- • When off inhaled O2-agonist for more than 4 hrs and theophylline for more than 24 hrs, FEV1 less than 65% predicted
- • Intubation for asthma at any time in the past
- • Need for 9 or more puffs/day of albuterol for each of 3 consecutive days (excluding preventive use prior to exercise), or nocturnal asthma awakenings more than 1.5 times per week on average, or average diary card symptom code greater than 2, or requirement for other medications to control asthma, during prn screening period
- • Inability to perform 3 acceptable FVC maneuvers of which at least 2 reproducible FEV1s are within 10% of the largest FEV1
- • Inability to complete the methacholine challenge or methacholine PC20 FEV1 greater than 12.5 mg/ml
- • Evidence that patient or family may be unreliable or non-compliant or may move from the metropolitan area before trial completion
About Johns Hopkins Bloomberg School Of Public Health
The Johns Hopkins Bloomberg School of Public Health is a leading institution dedicated to advancing public health research and education. Renowned for its rigorous academic programs and commitment to improving global health outcomes, the School conducts innovative clinical trials that address pressing health challenges. With a focus on evidence-based practices, multidisciplinary collaboration, and community engagement, the Bloomberg School leverages its extensive resources and expertise to contribute to the development of effective public health interventions and policies. Through its research endeavors, the School aims to enhance population health and inform health policy both locally and globally.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Trial Officials
N. F. Adkinson, MD
Principal Investigator
Johns Hopkins University
Anne Fuhlbrigge, MD, MS
Principal Investigator
Brigham and Women's Hospital
H. W. Kelly, PharmD
Principal Investigator
University of New Mexico
Padmaja Subbarao, MD, MSc
Principal Investigator
The Hospital for Sick Children
Paul Williams, MD
Principal Investigator
Asthma, Inc.
Robert Strunk, MD
Principal Investigator
Washington University School of Medicine
Stanley Szefler, MD
Principal Investigator
National Jewish Health
James Tonascia, PhD
Principal Investigator
Johns Hopkins University
Robert Zeiger, MD, PhD
Principal Investigator
University of California, San Diego
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Similar Trials