Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN)
Launched by CARELON RESEARCH · Oct 27, 1999
Trial Information
Current as of May 09, 2025
Completed
Keywords
ClinConnect Summary
BACKGROUND:
Cooley's anemia (beta-thalassemia major, hereafter referred to as thalassemia) is a severe, inherited blood disorder characterized by a quantitative defect in the synthesis of the beta chain of hemoglobin caused by any 1 of more than 100 known mutations in and around the beta globin gene cluster. The disease is characterized by severe anemia beginning in the first 6 to 12 months of life. If untreated, the life expectancy is less than 5 years of age. Chronic red blood cell transfusions to maintain hemoglobin levels between 9 and 11 gm/dl ("hypertransfusion") alleviate the anemia...
Gender
ALL
Eligibility criteria
- • Please refer to specific studies for eligibility criteria.
About Carelon Research
Carelon Research is a leading clinical trial sponsor dedicated to advancing healthcare through innovative research and development. With a focus on delivering high-quality clinical trials across various therapeutic areas, Carelon Research collaborates with healthcare professionals, institutions, and patients to ensure the integrity and efficacy of its studies. The organization is committed to ethical practices and compliance, fostering an environment of transparency and collaboration. By leveraging cutting-edge technology and a patient-centric approach, Carelon Research aims to accelerate the discovery of new therapies that enhance patient outcomes and contribute to the broader medical community.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Oakland, California, United States
Boston, Massachusetts, United States
New York, New York, United States
Philadelphia, Pennsylvania, United States
Toronto, Ontario, Canada
Patients applied
Trial Officials
Alan R. Cohen, MD
Principal Investigator
Children's Hospital of Philadelphia
Patricia J. Giardina, MD
Principal Investigator
Weill Medical College of Cornell University
Ellis J. Neufeld, MD, PhD
Principal Investigator
Children's Hospital Medical Center, Cincinnati
Nancy F. Olivieri, MD
Principal Investigator
Toronto General Hospital
Elliott P. Vichinsky, MD
Principal Investigator
UCSF Benioff Children's Hospital Oakland
Sonja McKinlay, PhD
Principal Investigator
New England Research Institutes, Inc.
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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