ClinConnect ClinConnect Logo
Search / Trial NCT00000623

Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN)

Launched by CARELON RESEARCH · Oct 27, 1999

Trial Information

Current as of May 09, 2025

Completed

Keywords

Chelator Iron Transfusion Anemia Thalassemia

ClinConnect Summary

BACKGROUND:

Cooley's anemia (beta-thalassemia major, hereafter referred to as thalassemia) is a severe, inherited blood disorder characterized by a quantitative defect in the synthesis of the beta chain of hemoglobin caused by any 1 of more than 100 known mutations in and around the beta globin gene cluster. The disease is characterized by severe anemia beginning in the first 6 to 12 months of life. If untreated, the life expectancy is less than 5 years of age. Chronic red blood cell transfusions to maintain hemoglobin levels between 9 and 11 gm/dl ("hypertransfusion") alleviate the anemia...

Gender

ALL

Eligibility criteria

  • Please refer to specific studies for eligibility criteria.

About Carelon Research

Carelon Research is a leading clinical trial sponsor dedicated to advancing healthcare through innovative research and development. With a focus on delivering high-quality clinical trials across various therapeutic areas, Carelon Research collaborates with healthcare professionals, institutions, and patients to ensure the integrity and efficacy of its studies. The organization is committed to ethical practices and compliance, fostering an environment of transparency and collaboration. By leveraging cutting-edge technology and a patient-centric approach, Carelon Research aims to accelerate the discovery of new therapies that enhance patient outcomes and contribute to the broader medical community.

Locations

Oakland, California, United States

Boston, Massachusetts, United States

New York, New York, United States

Philadelphia, Pennsylvania, United States

Toronto, Ontario, Canada

Patients applied

0 patients applied

Trial Officials

Alan R. Cohen, MD

Principal Investigator

Children's Hospital of Philadelphia

Patricia J. Giardina, MD

Principal Investigator

Weill Medical College of Cornell University

Ellis J. Neufeld, MD, PhD

Principal Investigator

Children's Hospital Medical Center, Cincinnati

Nancy F. Olivieri, MD

Principal Investigator

Toronto General Hospital

Elliott P. Vichinsky, MD

Principal Investigator

UCSF Benioff Children's Hospital Oakland

Sonja McKinlay, PhD

Principal Investigator

New England Research Institutes, Inc.

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Similar Trials