A Pharmacokinetic Study of L-697,661 Alone and in Combination With Zidovudine

Launched by MERCK SHARP & DOHME LLC · Aug 30, 2001

Keywords

ClinConnect Summary

L-697,661 is a newly identified compound that inhibits HIV replication (reproduction and growth) in cell culture. It works together with AZT against HIV.

Part 1: Twelve patients are randomly assigned to one of two groups. Group 1 patients receive AZT for 7 days, followed by AZT plus L-697,661 with food for 56 days. Group 2 patients receive no drug for 7 days, followed by L-697,661 with food for 56 days. Antipyrine is administered 1 hour prior to study drug on days 8, 22, and 35.

Part 2: Fifteen patients receive L-697,661 with food, for 8 weeks. Therapy with L-697,661 may be extended beyon...

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Eligibility criteria

• • Inclusion Criteria
• Patients must have:
• • HIV infection.
• Prior Medication: Included:
• • Patients in Part 1 must have received no previous zidovudine (AZT) or a stable dose of at least 500 mg/day without evidence of toxicity.
• • Patients in Part 2 must have received no previous AZT or = or \> 300 mg/day for \< 6 consecutive weeks within 1 year prior to study entry.
• • Exclusion Criteria
• Co-existing Condition:
• Patients with the following conditions or symptoms are excluded:
• • Acute HIV-related opportunistic infection requiring ongoing treatment.
• • Diarrhea defined as 3 or more liquid stools/day for one week.
• • Wilson's or Gilbert's disease, porphyria, or other chronic or acute hepatic disease.
• • Potentially life-threatening allergic reactions to any of the components of zidovudine.
• • Acute or chronic medical conditions that in the opinion of the investigator would place patient at risk by participation in this study.
• Concurrent Medication:
• Excluded:
• • Systemic bronchodilators, acetaminophen, aspirin.
• Prior Medication:
• Excluded:
• • Didanosine (ddI) or dideoxycytidine (ddC) within 14 days prior to entry.
• • Immune modulators or investigational drugs within 30 days prior to entry.
• • Drugs known to induce hepatocellular enzymes, such as phenobarbital, phenytoin, warfarin, ketoconazole, and oral contraceptives, within 30 days prior to entry.
• Patients in Part 2 only:
• Excluded:
• • Zidovudine within 4 weeks prior to receiving first dose of study drug.
• Risk Behavior:
• Excluded:
• • Patients who the investigator feels would not comply with study requirements.
• Patients may not have the following prior conditions:
• • Acute or chronic medical conditions that in the opinion of the investigator would place patient at risk by participation in this study.
• • Potentially life-threatening allergic reactions to any of the components of zidovudine.