A Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of 200 Mcg of gp120 (CHO) BIOCINE in MF59 Emulsion Versus the Emulsion Control: Three Injections at 0, 1, and 6 Months
Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001
Current as of December 10, 2023
Preliminary evaluations of two dose levels of gp120 administered to volunteers in protocol VEU 007A indicate that a gp120 dose of potentially greater immunogenicity may be of interest. Ten healthy volunteers receive 200 mcg gp120 in MF59 emulsion, and four volunteers receive placebo consisting of MF59 emulsion in PBS vehicle. Injections are given at months 0, 1, and 6. Patients are followed for 12 months following the third injection.
- Inclusion Criteria
- Subjects must have:
- Normal history and physical exam.
- Negative ELISA for HIV.
- Normal cell-mediated immune responses using Merieux skin test.
- Normal urinalysis.
- Exclusion Criteria
- Co-existing Condition:
- Subjects with the following conditions are excluded:
- Evidence of psychological or psychiatric problems that may lead to noncompliance with study requirements.
- Positive syphilis serology. If serology is documented as a false positive or is due to a remote (> 6 months) treated infection, subject is eligible.
- Circulating hepatitis B surface antigen.
- Subjects with the following prior conditions are excluded:
- History of immunodeficiency, chronic illness, autoimmune disease, or use of immunosuppressive medications.
- History of anaphylaxis or other adverse reactions to vaccines.
- Prior Medication:
- Prior HIV vaccines.
- Immunoglobulins or vaccines within the past 3 months.
- Experimental agents within the past 30 days.
- Prior Treatment:
- Blood transfusions or cryoprecipitates within the past 3 months.
- Identifiable high-risk behavior for HIV infection, including:
- Any history of intravenous (IV) drug use within the past year.
- Syphilis, gonorrhea, or any other sexually transmitted diseases (including chlamydia or pelvic inflammatory disease) in the past 6 months.
- More than two sexual partners, or sexual contact with a high-risk partner, in the past 6 months.
The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Seattle, Washington, United States
Nashville, Tennessee, United States
All reviews come from applied patients