A Study of the Effects of Giving Two Anti-HIV Vaccines to Babies of HIV-Positive Mothers

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001

Keywords

ClinConnect Summary

Transmission of HIV from an untreated infected mother to her offspring is thought to occur to some infants perinatally and others at parturition. It is possible that administration of an immunogenic vaccine can reduce the vertical transmission of HIV-1 or moderate its course in infected infants. Successful early sensitization to HIV epitopes might succeed in preventing HIV infection. Alternately, the enhancement of HIV-specific immune function might also succeed in modifying HIV replication and affecting disease progression.

Sixty infants are treated in this randomized, double-blind study;...

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• The infant may be eligible if the mother:
• • Is HIV-positive.
• • Is willing to follow the study guidelines.
• • Had her baby at Week 37 of pregnancy or later.
• • Exclusion Criteria
• The infant will not be eligible if the mother:
• • Has hepatitis B.
• • Is breast-feeding her baby.
• • Used certain medications during pregnancy.
• The infant will not be eligible if he/she:
• • Is more than 3 days old at study entry.
• • Has a serious infection or life-threatening illness.