Search / Trial NCT00000879

A Study of the Effects of Giving Two Anti-HIV Vaccines to Babies of HIV-Positive Mothers

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001

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Trial Information

Current as of May 26, 2024

Completed

Keywords

Pregnancy Pregnancy Complications, Infectious Aids Vaccines Disease Transmission, Vertical Avipoxvirus Hiv Preventive Vaccine Hiv Therapeutic Vaccine

Description

Transmission of HIV from an untreated infected mother to her offspring is thought to occur to some infants perinatally and others at parturition. It is possible that administration of an immunogenic vaccine can reduce the vertical transmission of HIV-1 or moderate its course in infected infants. Successful early sensitization to HIV epitopes might succeed in preventing HIV infection. Alternately, the enhancement of HIV-specific immune function might also succeed in modifying HIV replication and affecting disease progression. Sixty infants are treated in this randomized, double-blind study;...

Gender

All

Eligibility criteria

  • Inclusion Criteria
  • The infant may be eligible if the mother:
  • Is HIV-positive.
  • Is willing to follow the study guidelines.
  • Had her baby at Week 37 of pregnancy or later.
  • Exclusion Criteria
  • The infant will not be eligible if the mother:
  • Has hepatitis B.
  • Is breast-feeding her baby.
  • Used certain medications during pregnancy.
  • The infant will not be eligible if he/she:
  • Is more than 3 days old at study entry.
  • Has a serious infection or life-threatening illness.

Attachments

readout_NCT00000879_2024-05-26.pdf

4.5 MB

NCT00000879_study_protocol.pdf

4.5 MB

About company

The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.

Contacts

JC

Jennifer Cobb

Immunology at National Institute of Allergy and Infectious Diseases (NIAID)

Locations

Boston, Massachusetts, United States

San Francisco, California, United States

Chicago, Illinois, United States

Baltimore, Maryland, United States

Worcester, Massachusetts, United States

New York, New York, United States

Long Beach, California, United States

Torrance, California, United States

Syracuse, New York, United States

Philadelphia, Pennsylvania, United States

New Orleans, Louisiana, United States

Philadelphia, Pennsylvania, United States

Orange, California, United States

New York, New York, United States

Chicago, Illinois, United States

Bronx, New York, United States

Seattle, Washington, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Reviews (48)

4.6

All reviews come from applied patients

5 stars
41
4 stars
6
3 stars
2
2 stars
0
1 stars
0
Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Michael Foster
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Dries Vincent
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

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