Comparison of Two Drugs, Cidofovir and Ganciclovir, in Treating Patients With AIDS Who Have CMV Retinitis

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001

Keywords

ClinConnect Summary

While cidofovir is effective in suppressing retinitis and prolonging time to progression, no studies have compared cidofovir to other therapies and its place in the treatment of CMV retinitis remains unexplored. By combining the ganciclovir intraocular device (slows retinitis progression) with oral ganciclovir (has the potential to treat both the ocular disease and to suppress dissemination to the contralateral eye and the viscera), without the use of a central venous catheter, this combination has become increasingly common. For these reasons, a comparative trial of cidofovir to other ther...

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Eligibility criteria

• • Inclusion Criteria
• You may be eligible for this study if you:
• • Are 13 years of age or older (parent or guardian consent required if under 18).
• • Agree to practice sexual abstinence or use effective birth control during and for 90 days after the study.
• • Have AIDS.
• • Have CMV retinitis.
• • Exclusion Criteria
• You will not be eligible for this study if you:
• • Have a history of heart or kidney disease.
• • Have medical problems which would prevent you from completing the study.
• • Are pregnant.