Search / Trial NCT00000940

Five-Drug Anti-HIV Treatment Followed by Treatment Interruption in Patients Who Have Recently Been Infected With HIV

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001

Trial Information

Current as of December 26, 2024

Completed

Keywords

Drug Therapy, Combination Stavudine Amprenavir/Ritonavir Protease Inhibitors Lamivudine Vx 478 Reverse Transcriptase Inhibitors Anti Hiv Agents Viral Load Abacavir Sulfate Acute Infection Treatment Interruption

ClinConnect Summary

Acute, primary HIV infection represents a potentially unique opportunity to eradicate the infection. Although plasma viral load rises rapidly, the dominant infecting virus is relatively uniform genetically, and infection may not be fully established in all tissue sites until some time after exposure. Current antiretroviral therapy is able to reduce plasma viral load to unmeasurable levels in established infection. However, there are many questions that remain about the treatment of primary HIV infection. While it is assumed that aggressive antiretroviral regimens are required, it is not kno...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Acute HIV infection (recently infected with HIV or recent seroconversion)
  • Karnofsky status of 80 or greater within 14 days prior to study entry
  • Acceptable methods of contraception
  • Able and willing to give written informed consent
  • Exclusion Criteria:
  • Previously received anti-HIV drugs
  • Hepatitis within 30 days prior to study entry
  • Pancreatitis within 120 days prior to study entry
  • Radiation or chemotherapy within 30 days prior to study entry
  • Certain medications within 14 days prior to study entry
  • Experimental or investigational therapy within 30 days prior to study entry
  • Illness (non-HIV infection, cancer, etc.) at the time of study entry
  • Pregnant or breastfeeding

Trial Officials

Paul Volberding, MD

Study Chair

San Francisco Veterans Medical Center

Elizabeth Connick, MD

Study Chair

Infectious Disease Division, University of Colorado Health Sciences Center

About National Institute Of Allergy And Infectious Diseases (Niaid)

The National Institute of Allergy and Infectious Diseases (NIAID) is a key component of the National Institutes of Health (NIH) dedicated to advancing the understanding, prevention, and treatment of infectious and immune-mediated diseases. Through rigorous clinical trials, NIAID aims to foster innovative research that enhances public health and addresses global health challenges, including emerging infectious diseases and allergies. The institute collaborates with various partners, including academic institutions, industry, and international organizations, to translate scientific discoveries into effective therapies and vaccines. NIAID's commitment to high-quality clinical research is integral to improving health outcomes and informing policy decisions in the realm of infectious diseases and immunology.

Locations

Los Angeles, California, United States

Los Angeles, California, United States

San Diego, California, United States

San Francisco, California, United States

Aurora, Colorado, United States

Honolulu, Hawaii, United States

Boston, Massachusetts, United States

Saint Louis, Missouri, United States

New York, New York, United States

Rochester, New York, United States

Chapel Hill, North Carolina, United States

Philadelphia, Pennsylvania, United States

Fall River, Massachusetts, United States

New York, New York, United States

New York, New York, United States

Rochester, New York, United States

Rochester, New York, United States

Providence, Rhode Island, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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