Search / Trial NCT00001025

Evaluation of Patients Who Have Not Had Success With Zidovudine

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001

Apply for Trial

Trial Information

Current as of December 10, 2023

Completed

Keywords

Virus Replication Didanosine Acquired Immunodeficiency Syndrome Aids Related Complex Zidovudine

Description

High-grade resistance to AZT has been detected in HIV isolates from approximately 25 percent of individuals with AIDS who received AZT for at least 1 year. To elucidate the clinical significance of in vitro AZT resistance, it is necessary to distinguish between clinical failure caused by AZT resistance and clinical decompensation caused by other factors. One hundred-twenty patients who have been receiving AZT for at least 1 year are randomized to 1) continue with AZT, 2) switch to treatment with didanosine at 1 of 2 doses, or 3) receive both AZT and ddI. Treatment is given for 16 weeks, wi...

Gender

All

Eligibility criteria

  • Inclusion Criteria
  • Concurrent Medication:
  • Allowed:
  • Chemoprophylaxis against Pneumocystis carinii pneumonia (PCP), Mycobacterium tuberculosis, or Herpes simplex virus, or against other opportunistic infections as indicated.
  • Corticosteroids for no longer than 21 days (only as part of PCP therapy).
  • Erythropoietin and G-CSF.
  • Patients must have:
  • Documented HIV-seropositivity.
  • CD4 count 100 - 300 cells/mm3.
  • Prior continuous AZT dose = or > 300 mg/day for 1 year or longer.
  • Prior Medication: Required:
  • AZT for at least 1 year prior to study entry.
  • Exclusion Criteria
  • Co-existing Condition:
  • Patients with the following symptoms and conditions are excluded:
  • Medical contraindication or is considered noncompliant in the opinion of the investigator.
  • Peripheral neuropathy = or > grade 2.
  • Concurrent Medication:
  • Excluded:
  • Anti-HIV agents other than study drugs.
  • Biologic response modifiers (other than erythropoietin or G-CSF).
  • Systemic cytotoxic chemotherapy.
  • Regularly prescribed medications (such as antipyretics, analgesics, allergy medications) that are associated with an increased risk of pancreatitis, peripheral neuropathy, or bone marrow suppression.
  • Concurrent Treatment:
  • Excluded:
  • Radiation therapy.
  • Patients with the following prior conditions are excluded:
  • History of acute or chronic pancreatitis, gout, or uric acid nephropathy.
  • Prior Medication:
  • Excluded:
  • Other antiretrovirals besides AZT.
  • ddI or ddC for more than 30 days within the past year or any time within 3 months prior to study entry.
  • Acute therapy for an infection or other medical illness within 14 days prior to study entry.

Attachments

readout_NCT00001025_2023-12-10.pdf

4.5 MB

NCT00001025_study_protocol.pdf

4.5 MB

About company

The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.

Contacts

JC

Jennifer Cobb

Immunology at National Institute of Allergy and Infectious Diseases (NIAID)

Locations

Birmingham, Alabama, United States

Springfield, Massachusetts, United States

San Francisco, California, United States

Chicago, Illinois, United States

Chicago, Illinois, United States

Seattle, Washington, United States

Chicago, Illinois, United States

Rochester, New York, United States

San Jose, California, United States

Stanford, California, United States

Chicago, Illinois, United States

Omaha, Nebraska, United States

Brooklyn, New York, United States

Buffalo, New York, United States

Syracuse, New York, United States

Minneapolis, Minnesota, United States

Denver, Colorado, United States

Denver, Colorado, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Reviews (48)

4.6

All reviews come from applied patients

5 stars
41
4 stars
6
3 stars
2
2 stars
0
1 stars
0
Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Michael Foster
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Dries Vincent
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Discussion 0