A Blood Test to Look at Cells of the Immune System in Healthy Children

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001

Keywords

ClinConnect Summary

Early in life, the cells involved in immune selection differentiate into CD4+ and CD8+ cells. Currently there is insufficient information on the cell maturation and activation of these peripheral blood mononuclear cell (PBMC) subsets in normal children. The critical need for this information has been brought about by the pediatric HIV/AIDS epidemic, which requires the measurement of peripheral blood CD4+ T cells and other cells types for interpretation of HIV disease progression. The immunopathogenesis of pediatric HIV infection differs from that in adults but is not well understood. In ord...

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Eligibility criteria

• • Inclusion Criteria
• A child may be eligible for this study if he/she:
• • Is 0 - 18 years old.
• • Is HIV-negative and is born to an HIV-negative mother.
• • Is healthy (no serious infection or disease).
• • Has signed informed consent of a parent or legal guardian if under 18.
• • Exclusion Criteria
• A child will not be eligible for this study if he/she:
• • Is pregnant or breast-feeding.
• • Has already completed this study once before.
• • Is taking prescription medications other than prescription vitamins.

Trial Officials