A Study of the Effectiveness of an HIV Vaccine (ALVAC vCP205) to Boost Immune Functions in HIV-Negative Volunteers Who Have Already Received an HIV Vaccine

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001

Keywords

ClinConnect Summary

Vaccines may provide a route of therapy against HIV-1 infections by boosting the immune system responses. An artificially constructed HIV-1 vaccine (NYCBH), using vaccinia virus as its vector, has the advantage of conferring both cellular and humoral immune responses that are long-lived. Studies have shown that a second artificially constructed vector vaccine, HIV-1 canarypox (vCP205), also increases CD8+ cytotoxic T lymphocyte (CTL) activity, a cell-mediated immune response. Yet, immune responses are not boosted in volunteers previously vaccinated with vaccinia-based HIV-1 vaccines when a ...

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Eligibility criteria

• • Inclusion Criteria
• You may be eligible for this study if you:
• • Are 18-60 years old.
• • Are willing to use adequate birth control for 1 month before study entry and during the study.
• • Have a CD4 count of at least 400 cells/mm3.
• • Have a normal medical history and physical examination.
• • Are available for 3 months of follow-up.
• • Have participated in AVEG Protocol 014C or 022A and received all the scheduled vaccinations 24 or more months before this study, or have never participated in HIV-vaccine studies.
• • Are HIV-negative within 8 weeks of study entry.
• • Are negative for hepatitis B surface antigen.
• • Exclusion Criteria
• You will not be eligible for this study if you:
• • Are pregnant or breast-feeding.
• • Have a history of an immune system problem, any long-term illness, or any autoimmune disease.
• • Have a history of using medications which affect your immune system.
• • Have a history of cancer, except if it has been removed with surgery and cure is most likely.
• • Have a medical or mental condition which interferes with the study.
• • Have a job or work which interferes with the study.
• • Have ever attempted suicide, thought of attempting suicide, or have a severe mental condition.
• • Have received vaccines within 60 days of study entry.
• • Have used experimental drugs within 30 days prior to study entry.
• • Have received any blood products, such as immunoglobulin, in the last 6 months.
• • Have active syphilis.
• • Have active tuberculosis.
• • Have any history of severe allergic reactions, including reactions to vaccines.
• • Have an allergy to egg products or neomycin.