A Study of the Effectiveness of an HIV Vaccine (ALVAC vCP205) to Boost Immune Functions in HIV-Negative Volunteers Who Have Already Received an HIV Vaccine
Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001
Current as of December 10, 2023
Vaccines may provide a route of therapy against HIV-1 infections by boosting the immune system responses. An artificially constructed HIV-1 vaccine (NYCBH), using vaccinia virus as its vector, has the advantage of conferring both cellular and humoral immune responses that are long-lived. Studies have shown that a second artificially constructed vector vaccine, HIV-1 canarypox (vCP205), also increases CD8+ cytotoxic T lymphocyte (CTL) activity, a cell-mediated immune response. Yet, immune responses are not boosted in volunteers previously vaccinated with vaccinia-based HIV-1 vaccines when a ...
- Inclusion Criteria
- You may be eligible for this study if you:
- Are 18-60 years old.
- Are willing to use adequate birth control for 1 month before study entry and during the study.
- Have a CD4 count of at least 400 cells/mm3.
- Have a normal medical history and physical examination.
- Are available for 3 months of follow-up.
- Have participated in AVEG Protocol 014C or 022A and received all the scheduled vaccinations 24 or more months before this study, or have never participated in HIV-vaccine studies.
- Are HIV-negative within 8 weeks of study entry.
- Are negative for hepatitis B surface antigen.
- Exclusion Criteria
- You will not be eligible for this study if you:
- Are pregnant or breast-feeding.
- Have a history of an immune system problem, any long-term illness, or any autoimmune disease.
- Have a history of using medications which affect your immune system.
- Have a history of cancer, except if it has been removed with surgery and cure is most likely.
- Have a medical or mental condition which interferes with the study.
- Have a job or work which interferes with the study.
- Have ever attempted suicide, thought of attempting suicide, or have a severe mental condition.
- Have received vaccines within 60 days of study entry.
- Have used experimental drugs within 30 days prior to study entry.
- Have received any blood products, such as immunoglobulin, in the last 6 months.
- Have active syphilis.
- Have active tuberculosis.
- Have any history of severe allergic reactions, including reactions to vaccines.
- Have an allergy to egg products or neomycin.
The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
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