Search / Trial NCT00001154

Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins

Launched by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI) · Nov 3, 1999

Trial Information

Current as of December 27, 2024

Completed

Keywords

Metabolism Hdl Cholesterol Ldl Hypoalphalipoproteinemia Natural History

ClinConnect Summary

We propose to investigate human in vivo lipoprotein metabolism using radiolabeled apolipoproteins on plasma lipoproteins. Paired kinetic studies using dual-labeled iodinated lipoproteins and apolipoproteins are performed in healthy volunteer controls with normal lipids and subjects with dyslipidemia under controlled metabolic conditions. Studies are designed to formulate metabolic pathways in patients with undefined genetic disorders of lipid metabolism as well as in healthy volunteers to provide original insights into normal and pathologic metabolic pathways. All kinetic data is computer a...

Gender

ALL

Eligibility criteria

  • * INCLUSION CRITERIA:
  • Subjects with new and undefined dyslipidemia-particularly familial disorders with extreme phenotypes.
  • Healthy normal volunteers - (18 years old or older) controls to investigate the formation of HDL for prebeta HDL.
  • Euthyroid.
  • EXCLUSION CRITERIA:
  • Healthy control volunteers are initially screened for secondary causes of hyperlipidemia and are excluded if they have any clinically significant laboratory abnormality (i.e., liver disease, disease, kidney disease, endocrine disease,), chronic medical problems (i.e., hypertension, migraines, inflammatory bowel, hepatitis, HIV) or require any chronic medications (i.e., acne, asthma).
  • The healthy control volunteers weight must fall within the current guidelines for ideal body weight.
  • Pregnant women.
  • Unwilling to follow metabolic diet.
  • Allergic to iodine.
  • Unable to sign consent form.

Trial Officials

Robert D Shamburek, M.D.

Principal Investigator

National Heart, Lung, and Blood Institute (NHLBI)

About National Heart, Lung, And Blood Institute (Nhlbi)

The National Heart, Lung, and Blood Institute (NHLBI) is a leading component of the National Institutes of Health (NIH), dedicated to advancing research and clinical trials focused on cardiovascular, pulmonary, and hematologic diseases. With a mission to improve public health through innovative research, the NHLBI supports a wide range of studies aimed at understanding, preventing, and treating heart and lung conditions. By collaborating with academic institutions, healthcare providers, and patient communities, the NHLBI strives to translate scientific discoveries into effective clinical practices, ultimately enhancing the quality of life for individuals affected by these critical health issues.

Locations

Bethesda, Maryland, United States

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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