Trials
Search / Trial NCT00001166

Gyrate Atrophy of the Choroid and Retina

Launched by NATIONAL EYE INSTITUTE (NEI) · Nov 3, 1999

Trial Information

Current as of January 15, 2025

Completed

Keywords

Hyperornithinemia Ornithine Aminotransferase (Oat) Tissue Culture Pyridoxine Hydrochloride Pyridoxal Phosphate Arginine Skin Fibroblast Gyrate Atrophy Autosomal Recessive Retinitis Pigmentosa Bietti's Crystalline Retinopathy Chorioretinal Degeneration

ClinConnect Summary

Gyrate atrophy of the choroid and retina (GA) is a rare autosomal recessive chorioretinal degeneration characterized by myopia, cataract, varying degrees of night blindness, and progressive constriction of visual fields associated with chorioretinal atrophy resulting in blindness. The objectives of this protocol are threefold:

1. Document the natural history of gyrate atrophy.
2. Relate the clinical course to the gene defect to explore the genetic heterogeneity inherent in this disease.
3. Assess the clinical course and laboratory findings of the effects of an arginine-deficient diet. The ...

Gender

ALL

Eligibility criteria

  • INCLUSION CRITERIA:
  • Patients must have hyperornithemia and a deficiency of OAT activity to enter the study.

About National Eye Institute (Nei)

The National Eye Institute (NEI), part of the U.S. National Institutes of Health (NIH), is dedicated to conducting and supporting innovative research to understand, prevent, and treat eye diseases and vision disorders. As a leading sponsor of clinical trials, NEI aims to advance knowledge in ocular health through rigorous scientific inquiry and collaboration with researchers, healthcare professionals, and institutions. By fostering the development of new therapies and technologies, NEI plays a pivotal role in enhancing the quality of life for individuals affected by visual impairments and eye conditions.

Locations

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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