Nctid:
NCT00001171
Payload:
{"FullStudy"=>{"Rank"=>474453, "Study"=>{"DerivedSection"=>{"MiscInfoModule"=>{"VersionHolder"=>"December 08, 2023"}, "ConditionBrowseModule"=>{"ConditionMeshList"=>{"ConditionMesh"=>[{"ConditionMeshId"=>"D000009369", "ConditionMeshTerm"=>"Neoplasms"}, {"ConditionMeshId"=>"D000005909", "ConditionMeshTerm"=>"Glioblastoma"}, {"ConditionMeshId"=>"D000001932", "ConditionMeshTerm"=>"Brain Neoplasms"}, {"ConditionMeshId"=>"D000010911", "ConditionMeshTerm"=>"Pituitary Neoplasms"}, {"ConditionMeshId"=>"D000010900", "ConditionMeshTerm"=>"Pituitary Diseases"}]}, "ConditionAncestorList"=>{"ConditionAncestor"=>[{"ConditionAncestorId"=>"D000001254", "ConditionAncestorTerm"=>"Astrocytoma"}, {"ConditionAncestorId"=>"D000005910", "ConditionAncestorTerm"=>"Glioma"}, {"ConditionAncestorId"=>"D000018302", "ConditionAncestorTerm"=>"Neoplasms, Neuroepithelial"}, {"ConditionAncestorId"=>"D000017599", "ConditionAncestorTerm"=>"Neuroectodermal Tumors"}, {"ConditionAncestorId"=>"D000009373", "ConditionAncestorTerm"=>"Neoplasms, Germ Cell and Embryonal"}, {"ConditionAncestorId"=>"D000009370", "ConditionAncestorTerm"=>"Neoplasms by Histologic Type"}, {"ConditionAncestorId"=>"D000009375", "ConditionAncestorTerm"=>"Neoplasms, Glandular and Epithelial"}, {"ConditionAncestorId"=>"D000009380", "ConditionAncestorTerm"=>"Neoplasms, Nerve Tissue"}, {"ConditionAncestorId"=>"D000016543", "ConditionAncestorTerm"=>"Central Nervous System Neoplasms"}, {"ConditionAncestorId"=>"D000009423", "ConditionAncestorTerm"=>"Nervous System Neoplasms"}, {"ConditionAncestorId"=>"D000009371", "ConditionAncestorTerm"=>"Neoplasms by Site"}, {"ConditionAncestorId"=>"D000001927", "ConditionAncestorTerm"=>"Brain Diseases"}, {"ConditionAncestorId"=>"D000002493", "ConditionAncestorTerm"=>"Central Nervous System Diseases"}, {"ConditionAncestorId"=>"D000009422", "ConditionAncestorTerm"=>"Nervous System Diseases"}, {"ConditionAncestorId"=>"D000007027", "ConditionAncestorTerm"=>"Hypothalamic Diseases"}, {"ConditionAncestorId"=>"D000004700", "ConditionAncestorTerm"=>"Endocrine System Diseases"}, {"ConditionAncestorId"=>"D000004701", "ConditionAncestorTerm"=>"Endocrine Gland Neoplasms"}, {"ConditionAncestorId"=>"D000007029", "ConditionAncestorTerm"=>"Hypothalamic Neoplasms"}, {"ConditionAncestorId"=>"D000015173", "ConditionAncestorTerm"=>"Supratentorial Neoplasms"}]}, "ConditionBrowseLeafList"=>{"ConditionBrowseLeaf"=>[{"ConditionBrowseLeafId"=>"M3281", "ConditionBrowseLeafName"=>"Adenoma", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M13492", "ConditionBrowseLeafName"=>"Pituitary Neoplasms", "ConditionBrowseLeafAsFound"=>"Pituitary Neoplasms", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"M13481", "ConditionBrowseLeafName"=>"Pituitary Diseases", "ConditionBrowseLeafAsFound"=>"Pituitary", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"M8710", "ConditionBrowseLeafName"=>"Glioma", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M8709", "ConditionBrowseLeafName"=>"Glioblastoma", "ConditionBrowseLeafAsFound"=>"Glioblastoma", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"M4899", "ConditionBrowseLeafName"=>"Brain Neoplasms", "ConditionBrowseLeafAsFound"=>"Brain Neoplasms", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"M4251", "ConditionBrowseLeafName"=>"Astrocytoma", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M20136", "ConditionBrowseLeafName"=>"Neoplasms, Neuroepithelial", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M19535", "ConditionBrowseLeafName"=>"Neuroectodermal Tumors", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M20078", "ConditionBrowseLeafName"=>"Neuroectodermal Tumors, Primitive", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M12008", "ConditionBrowseLeafName"=>"Neoplasms, Germ Cell and Embryonal", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M12005", "ConditionBrowseLeafName"=>"Neoplasms by Histologic Type", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M12010", "ConditionBrowseLeafName"=>"Neoplasms, Glandular and Epithelial", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M12015", "ConditionBrowseLeafName"=>"Neoplasms, Nerve Tissue", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M12057", "ConditionBrowseLeafName"=>"Nervous System Neoplasms", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M18627", "ConditionBrowseLeafName"=>"Central Nervous System Neoplasms", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M4894", "ConditionBrowseLeafName"=>"Brain Diseases", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M5432", "ConditionBrowseLeafName"=>"Central Nervous System Diseases", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M9767", "ConditionBrowseLeafName"=>"Hypothalamic Diseases", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M7552", "ConditionBrowseLeafName"=>"Endocrine System Diseases", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M7553", "ConditionBrowseLeafName"=>"Endocrine Gland Neoplasms", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M9769", "ConditionBrowseLeafName"=>"Hypothalamic Neoplasms", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M17577", "ConditionBrowseLeafName"=>"Supratentorial Neoplasms", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"T2519", "ConditionBrowseLeafName"=>"Glioma", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"T2518", "ConditionBrowseLeafName"=>"Glioblastoma", "ConditionBrowseLeafAsFound"=>"Glioblastoma", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"T4092", "ConditionBrowseLeafName"=>"Neuroepithelioma", "ConditionBrowseLeafRelevance"=>"low"}]}, "ConditionBrowseBranchList"=>{"ConditionBrowseBranch"=>[{"ConditionBrowseBranchName"=>"Neoplasms", "ConditionBrowseBranchAbbrev"=>"BC04"}, {"ConditionBrowseBranchName"=>"All Conditions", "ConditionBrowseBranchAbbrev"=>"All"}, {"ConditionBrowseBranchName"=>"Nervous System Diseases", "ConditionBrowseBranchAbbrev"=>"BC10"}, {"ConditionBrowseBranchName"=>"Gland and Hormone Related Diseases", "ConditionBrowseBranchAbbrev"=>"BC19"}, {"ConditionBrowseBranchName"=>"Rare Diseases", "ConditionBrowseBranchAbbrev"=>"Rare"}]}}}, "ProtocolSection"=>{"DesignModule"=>{"StudyType"=>"Observational", "EnrollmentInfo"=>{"EnrollmentCount"=>"800"}}, "StatusModule"=>{"OverallStatus"=>"Completed", "StartDateStruct"=>{"StartDate"=>"July 1979"}, "ExpandedAccessInfo"=>{"HasExpandedAccess"=>"No"}, "StatusVerifiedDate"=>"September 2005", "CompletionDateStruct"=>{"CompletionDate"=>"September 2005"}, "LastUpdateSubmitDate"=>"March 3, 2008", "StudyFirstSubmitDate"=>"November 3, 1999", "StudyFirstSubmitQCDate"=>"November 3, 1999", "LastUpdatePostDateStruct"=>{"LastUpdatePostDate"=>"March 4, 2008", "LastUpdatePostDateType"=>"Estimate"}, "StudyFirstPostDateStruct"=>{"StudyFirstPostDate"=>"November 4, 1999", "StudyFirstPostDateType"=>"Estimate"}}, "OversightModule"=>{}, "ConditionsModule"=>{"KeywordList"=>{"Keyword"=>["Brain Tumors", "Glioma", "Glioblastoma Multiforme", "Pituitary Adenoma"]}, "ConditionList"=>{"Condition"=>["Brain Neoplasm", "Glioblastoma", "Glioma", "Pituitary Neoplasm"]}}, "ReferencesModule"=>{"ReferenceList"=>{"Reference"=>[{"ReferencePMID"=>"9145719", "ReferenceType"=>"background", "ReferenceCitation"=>"Manski TJ, Heffner DK, Glenn GM, Patronas NJ, Pikus AT, Katz D, Lebovics R, Sledjeski K, Choyke PL, Zbar B, Linehan WM, Oldfield EH. Endolymphatic sac tumors. A source of morbid hearing loss in von Hippel-Lindau disease. JAMA. 1997 May 14;277(18):1461-6. doi: 10.1001/jama.277.18.1461."}, {"ReferencePMID"=>"9285597", "ReferenceType"=>"background", "ReferenceCitation"=>"Mason RB, Nieman LK, Doppman JL, Oldfield EH. Selective excision of adenomas originating in or extending into the pituitary stalk with preservation of pituitary function. J Neurosurg. 1997 Sep;87(3):343-51. doi: 10.3171/jns.1997.87.3.0343."}, {"ReferencePMID"=>"8609564", "ReferenceType"=>"background", "ReferenceCitation"=>"Zunkeler B, Carson RE, Olson J, Blasberg RG, Girton M, Bacher J, Herscovitch P, Oldfield EH. Hyperosmolar blood-brain barrier disruption in baboons: an in vivo study using positron emission tomography and rubidium-82. J Neurosurg. 1996 Mar;84(3):494-502. doi: 10.3171/jns.1996.84.3.0494."}]}}, "DescriptionModule"=>{"BriefSummary"=>"Presently, patients with primary malignant brain tumors have a life expectancy of 15 weeks following surgery unless they receive additional types of therapy (chemotherapy, radiotherapy, and/or immunotherapy). Patients that receive additional therapy can increase life expectancy to 50 weeks.\n\nThe statistics on the life expectancy and survival have increased efforts among researchers to develop new treatments for primary malignant brain tumors.\n\nThis research project involves the growth and study of human brain tumor cells outside the body in the laboratory as part of an attempt to better understand these tumors and to develop more effective treatments for them.", "DetailedDescription"=>"This protocol involves the study of human brain tumor cells outside the body in the laboratory as part of an attempt to better understand these tumors and to develop more effective therapeutic measures.\n\nMalignant primary brain tumor patients at present have a life expectancy of approximately 15 weeks following surgery unless other adjunctive measures are taken. With currently available adjunctive therapy the life expectancy reaches 50 weeks.\n\nThese survival data have spurred extensive efforts to develop new treatment modalities. Radiation, chemotherapy and immunotherapy have been mildly helpful adjuncts but their use has been largely on empirical grounds or on the basis of experimentation on animal tumor models often quite different in nature from human brain tumors.\n\nOur group has sought to develop data upon which to devise new treatment strategies for patients with malignant brain tumors.\n\nThe foundation of our approach rests upon the use of in vitro studies of the cell biology of each patient's tumor.\n\nIt is our plan to utilize these tumors for in vitro investigation of the immunology, biology, biochemistry and molecular biology of brain tumors. Optimal conventional therapy will be given to the patients as we seek to learn more of how the scientific information obtained can be used to help them."}, "EligibilityModule"=>{"Gender"=>"All", "StdAgeList"=>{"StdAge"=>["Child", "Adult", "Older Adult"]}, "HealthyVolunteers"=>"No", "EligibilityCriteria"=>"INCLUSION CRITERIA:\n\nPatients to be studied will have either undergone surgical confirmation of a malignant primary brain tumor or be considered likely to have that diagnosis on the basis of diagnostic studies.\n\nThey should have survival likelihood of at least three months and be able to comprehend the nature of the proposed program."}, "IdentificationModule"=>{"NCTId"=>"NCT00001171", "BriefTitle"=>"Evaluation of Factors in Human Brain Tumors", "Organization"=>{"OrgClass"=>"NIH", "OrgFullName"=>"National Institutes of Health Clinical Center (CC)"}, "OfficialTitle"=>"Evaluation of Biological, Immunological and Therapeutic Parameters in Brain Tumor Patients", "OrgStudyIdInfo"=>{"OrgStudyId"=>"790089"}, "SecondaryIdInfoList"=>{"SecondaryIdInfo"=>[{"SecondaryId"=>"79-N-0089"}]}}, "ContactsLocationsModule"=>{"LocationList"=>{"Location"=>[{"LocationZip"=>"20892", "LocationCity"=>"Bethesda", "LocationState"=>"Maryland", "LocationCountry"=>"United States", "LocationFacility"=>"National Institute of Neurological Disorders and Stroke (NINDS)"}]}}, "SponsorCollaboratorsModule"=>{"LeadSponsor"=>{"LeadSponsorName"=>"National Institute of Neurological Disorders and Stroke (NINDS)", "LeadSponsorClass"=>"NIH"}}}}}}
