A Multimodality Treatment Approach to Patients With Inflammatory Cancer of the Breast and Locally Advanced Non-Inflammatory Stage III Breast Cancer and Stage IV Breast Cancer

Launched by NATIONAL CANCER INSTITUTE (NCI) · Dec 9, 2002

Keywords

ClinConnect Summary

This study is designed to evaluate the efficacy of high dose melphalan and autologous bone marrow transplantation given as consolidation therapy to patients with inflammatory or metastatic carcinoma of the breast in complete remission. All patients entered will receive induction therapy with cyclophosphamide, adriamycin, methotrexate and 5-fluorouracil with hormonal synchronization utilizing tamoxifen and premarin as in a previous Medicine Branch protocol (MB-160C). Among patients with inflammatory carcinoma of the breast, pathologic complete responders will receive irradiation to the breas...

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ALL

Eligibility criteria

• • Patients must have a histologically documented diagnosis of mammary carcinoma and evaluable disease in the breast.
• • Diagnostic tissue must be reviewed at NIH.
• • All ICB patients must meet Haagensen's clinical criteria of ICB.
• • Patients with metastatic breast cancer must have evaluable disease.
• • There must be no history of prior cytotoxic therapy.
• • There must be no history of previous malignancy except for cured nonmelanoma skin cancer and cervical carcinoma in situ.
• • Performance status (Karnofsky scale) must be greater than 30 for patients with metastatic breast cancer.
• • Staging workup must be negative for distant metastases in Stage III patients.
• • WBC count greater than 4000 per mm(3) and platelet count greater than 100,000 per mm(3).
• • Normal hepatic and renal function, unless due to tumor involvement.
• • Patients must be willing to give informed consent and be geographically accessible for follow up.
• • No history of other malignant neoplasms except for curatively treated nonmelanoma skin cancer or surgically cured carcinoma of the cervix in situ.
• • Patients must not be poor medical or psychiatric risks because of non-malignant systemic disease which would preclude them being subjected to any of the treatments in this protocol.