Biological Markers in Attention Deficit/Hyperactivity Disorder (ADHD)

Launched by NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH) · Nov 3, 1999

Keywords

ClinConnect Summary

This protocol allows the continuing prospective longitudinal study of ADHD probands for whom we have neurobiological measures, particularly quantitative brain MRI. The follow-up consists of structured psychiatric interviews, and neuropsychological tests. Repeat MRI scans are obtained through protocol 89-M-0006.

The second purpose of this protocol is a study of the genetics of Attention-Deficit/Hyperactivity Disorder (ADHD). Subjects who have ADHD, their family members, and controls are studied under this protocol.

Gender

ALL

Eligibility criteria

• * INCLUSION REQUIREMENTS-PROBANDS:
• • Current age of index probands: 15.21 plus or minus 3.42; previous participation in the NIMH Child Psychiatry Branch ADHD study.
• • Age adjusted dimensional ratings (Conners Rating Scales-Revised, and Strengths and Weaknesses of ADHD and Normal Behavior (SWAN)) of hyperactivity/impulsivity greater than or equal to 95th percentile for index and second sibling. Primary ratings for the index proband will be provided by main teacher.
• • Up to 150 ADHD probands for reassessment.
• • Consent and assent obtained in writing.
• EXCLUSION CRITERIA - PROBANDS:
• • Presence of other known genetic conditions that are likely to be etiologic.
• • Onset of medical conditions that could produce symptoms of ADHD through non-genetic mechanisms (e.g., thyroid disorders, seizure disorders, inborn errors of metabolism, extremely low birth weight (less than 1000 gm), meningitis, intracranial pathology).
• • Presence of other psychiatric disorders that can produce symptoms similar to ADHD (e.g., major depression, bipolar disorder, severe anxiety disorders, pervasive developmental disorders, psychotic disorders, post-traumatic stress disorder).
• • Presence of neuropsychiatric conditions that may confound evaluation of ADHD (e.g., Tourette's syndrome, obsessive-compulsive disorder, or PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcus), intelligence quotient less than 80, reading achievement standard scores less than 75 or reading-intelligence discrepancy greater than 2 SD).
• INCLUSION REQUIRMENTS-RELATIVES:
• • Subjects must be relatives of probands.
• • Consent and assent obtained in writing.
• INCLUSION REQUIREMENTS -NORMAL VOLUNTEERS:
• • Up to 150 newly accrued normal volunteers unrelated to probands.
• • Same age range as probands.
• • Parent and teacher ratings within one SD of population means on ADHD/hyperactivity factors.
• • Consent and assent obtained in writing.
• EXCLUSIONS - NORMAL VOLUNTEERS:
• • Presence of ADHD.
• • Presence of any other psychiatric disorders on structured psychiatric interview (DICA-IV).
• • Presence of known genetic conditions.
• • Onset, presence or history of medical conditions that could produce symptoms of ADHD through non-genetic mechanisms (e.g., thyroid disorders, seizure disorders, inborn errors of metabolism, extremely low birth weight (less than 1000 gm), meningitis, intracranial pathology).