Cysteamine Eye Drops to Treat Corneal Crystals in Cystinosis
Launched by NATIONAL EYE INSTITUTE (NEI) · Nov 3, 1999
Trial Information
Current as of May 09, 2025
Completed
Keywords
ClinConnect Summary
Protocol 86-EI-0062 began as a randomized, double-masked, placebo controlled study to evaluate the efficacy and safety of 0.5% topical cysteamine but was subsequently amended as a natural history protocol. Additional protocols conducted at the National Eye Institute (NEI) at the National Institutes of Health (NIH) began after this protocol and tested various formulations of cysteamine topical solution for efficacy and safety in patients with cystinosis. Subjects from these NIH protocols testing various formulations were ultimately transferred to this natural history protocol for open-label ...
Gender
ALL
Eligibility criteria
- INCLUSION CRITERIA:
- • Patients must have a documented clinical diagnosis of cystinosis.
- • Patients should be 2 years old or older.
- EXCLUSION CRITERIA:
- • Inability to travel to NIH for a baseline examination, after 1 year, and every two years thereafter for follow-up
- • Inability to cooperate for slit-lamp examination
About National Eye Institute (Nei)
The National Eye Institute (NEI), part of the U.S. National Institutes of Health (NIH), is dedicated to conducting and supporting innovative research to understand, prevent, and treat eye diseases and vision disorders. As a leading sponsor of clinical trials, NEI aims to advance knowledge in ocular health through rigorous scientific inquiry and collaboration with researchers, healthcare professionals, and institutions. By fostering the development of new therapies and technologies, NEI plays a pivotal role in enhancing the quality of life for individuals affected by visual impairments and eye conditions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Bethesda, Maryland, United States
Patients applied
Trial Officials
Rachel J Bishop, M.D.
Principal Investigator
National Eye Institute (NEI)
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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