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Search / Trial NCT00001213

Cysteamine Eye Drops to Treat Corneal Crystals in Cystinosis

Launched by NATIONAL EYE INSTITUTE (NEI) · Nov 3, 1999

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Trial Information

Current as of March 22, 2025

Completed

Keywords

Cysteamine Eye Drops Nephropathic Cystinosis Corneal Crystals Benzalkonium Toxicity Efficacy Cystinosis

ClinConnect Summary

Protocol 86-EI-0062 began as a randomized, double-masked, placebo controlled study to evaluate the efficacy and safety of 0.5% topical cysteamine but was subsequently amended as a natural history protocol. Additional protocols conducted at the National Eye Institute (NEI) at the National Institutes of Health (NIH) began after this protocol and tested various formulations of cysteamine topical solution for efficacy and safety in patients with cystinosis. Subjects from these NIH protocols testing various formulations were ultimately transferred to this natural history protocol for open-label ...

Gender

ALL

Eligibility criteria

  • INCLUSION CRITERIA:
  • • Patients must have a documented clinical diagnosis of cystinosis.
  • • Patients should be 2 years old or older.
  • EXCLUSION CRITERIA:
  • • Inability to travel to NIH for a baseline examination, after 1 year, and every two years thereafter for follow-up
  • • Inability to cooperate for slit-lamp examination

Trial Officials

Rachel J Bishop, M.D.

Principal Investigator

National Eye Institute (NEI)

About National Eye Institute (Nei)

The National Eye Institute (NEI), part of the U.S. National Institutes of Health (NIH), is dedicated to conducting and supporting innovative research to understand, prevent, and treat eye diseases and vision disorders. As a leading sponsor of clinical trials, NEI aims to advance knowledge in ocular health through rigorous scientific inquiry and collaboration with researchers, healthcare professionals, and institutions. By fostering the development of new therapies and technologies, NEI plays a pivotal role in enhancing the quality of life for individuals affected by visual impairments and eye conditions.

Locations

Bethesda, Maryland, United States

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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