The Effects of Estrogen on Cognition in Girls With Turner Syndrome

Launched by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT (NICHD) · Nov 3, 1999

Keywords

ClinConnect Summary

Estrogen influences brain development in females at puberty. Environmental and cultural factors interact with the biological effects of estrogen on the brain and consequently on cognition and behavior. Turner syndrome females lack endogenous estrogen as a result of dysgenetic ovaries. Turner syndrome therefore represents a unique, estrogen-deficient model in which to study the biological effects of estrogen on cognition and behavior. The specific aims of this project are to: 1) document further, the cognitive differences between girls with Turner syndrome at ages 5 to adult (less than or eq...

Gender

ALL

Eligibility criteria

• INCLUSION CRITERIA:
• • Patients will include girls and women ages 5-50 yr with the diagnosis of Turner syndrome based on absence of all or part of one of the X chromosomes.
• • Control subjects must be within +/- 2SD for height and weight and have normal intelligence and educational achievement.
• • Biological parents (both male and female) of TS subjects may be included in this study, but only to have blood drawn for genetic testing in order to determine the origin of the X-chromosome of their daughters.
• EXCLUSION CRITERIA:
• • Those with severe physical or neurocognitive impairment, preventing accurate completion of the cognitive tasks, will be excluded.
• • Normal subjects who have qualified for or participated in gifted and talented or remedial education programs.