Search / Trial NCT00001257

Inflammatory Responses in Normal Volunteers and Patients With Abnormal Immune Responses

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Nov 3, 1999

Trial Information

Current as of December 14, 2024

Terminated

Keywords

Lymphokines Ltb4 Inflammation Normal Volunteer Abnormal Phagocyte Function

ClinConnect Summary

Patients with abnormal regulation of inflammation and with host defense defects often have an exaggerated or depressed inflammatory response with resultant difficulty in healing of recurrent infections. Delayed healing can be manifested by either a delay in wound healing, granuloma formation along the incision line, or dehiscence of a partially healed wound without evidence of infection. We are interested in studying the dynamics of host immune defenses during an experimentally induced inflammatory response using a well-studied suction blister device. This protocol is designed to study medi...

Gender

ALL

Eligibility criteria

  • * INCLUSION CRITERIA - PATIENTS:
  • Patients having or thought to have an immune defect between the ages of 6 and 65 years (inclusive) are eligible to participate.
  • INCLUSION CRITERIA - NORMAL VOLUNTEERS:
  • Be a healthy adult of either sex and between the ages of 18 and 65 years old.
  • Weight greater than 110 pounds.
  • Not have any heart, lung, or kidney disease, or bleeding disorders.
  • Not have a history of viral hepatitis (B or C) since age 11.
  • Not have a history of intravenous injection drug use.
  • Not have a history of engaging in high-risk activities for exposure to the AIDS virus.
  • Not be pregnant.
  • EXCLUSION CRITERIA - PATIENTS:
  • Patients less than 6 or greater than 65 years of age.
  • EXCLUSION CRITERIA - NORMAL VOLUNTEER:
  • Less than 18 years old or older than 65 years.
  • Have viral hepatitis (B or C).
  • HIV positive.
  • Receiving chemotherapeutic agent(s), or have underlying malignancy.
  • Pregnant.
  • Have history of heart, lung, kidney disease, or bleeding disorders.

Trial Officials

Kol A Zarember, Ph.D.

Principal Investigator

National Institute of Allergy and Infectious Diseases (NIAID)

About National Institute Of Allergy And Infectious Diseases (Niaid)

The National Institute of Allergy and Infectious Diseases (NIAID) is a key component of the National Institutes of Health (NIH) dedicated to advancing the understanding, prevention, and treatment of infectious and immune-mediated diseases. Through rigorous clinical trials, NIAID aims to foster innovative research that enhances public health and addresses global health challenges, including emerging infectious diseases and allergies. The institute collaborates with various partners, including academic institutions, industry, and international organizations, to translate scientific discoveries into effective therapies and vaccines. NIAID's commitment to high-quality clinical research is integral to improving health outcomes and informing policy decisions in the realm of infectious diseases and immunology.

Locations

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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