Search / Trial NCT00001257

Inflammatory Responses in Normal Volunteers and Patients With Abnormal Immune Responses

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Nov 3, 1999

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Trial Information

Current as of June 14, 2024

Terminated

Keywords

Lymphokines Ltb4 Inflammation Normal Volunteer Abnormal Phagocyte Function

Description

Patients with abnormal regulation of inflammation and with host defense defects often have an exaggerated or depressed inflammatory response with resultant difficulty in healing of recurrent infections. Delayed healing can be manifested by either a delay in wound healing, granuloma formation along the incision line, or dehiscence of a partially healed wound without evidence of infection. We are interested in studying the dynamics of host immune defenses during an experimentally induced inflammatory response using a well-studied suction blister device. This protocol is designed to study medi...

Gender

All

Eligibility criteria

  • INCLUSION CRITERIA - PATIENTS:
  • Patients having or thought to have an immune defect between the ages of 6 and 65 years (inclusive) are eligible to participate.
  • INCLUSION CRITERIA - NORMAL VOLUNTEERS:
  • Be a healthy adult of either sex and between the ages of 18 and 65 years old.
  • Weight greater than 110 pounds.
  • Not have any heart, lung, or kidney disease, or bleeding disorders.
  • Not have a history of viral hepatitis (B or C) since age 11.
  • Not have a history of intravenous injection drug use.
  • Not have a history of engaging in high-risk activities for exposure to the AIDS virus.
  • Not be pregnant.
  • EXCLUSION CRITERIA - PATIENTS:
  • Patients less than 6 or greater than 65 years of age.
  • EXCLUSION CRITERIA - NORMAL VOLUNTEER:
  • Less than 18 years old or older than 65 years.
  • Have viral hepatitis (B or C).
  • HIV positive.
  • Receiving chemotherapeutic agent(s), or have underlying malignancy.
  • Pregnant.
  • Have history of heart, lung, kidney disease, or bleeding disorders.

Attachments

readout_NCT00001257_2024-06-14.pdf

4.5 MB

NCT00001257_study_protocol.pdf

4.5 MB

About company

The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.

Contacts

JC

Jennifer Cobb

Immunology at National Institute of Allergy and Infectious Diseases (NIAID)

Locations

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Ongoing

Reviews (48)

4.6

All reviews come from applied patients

5 stars
41
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Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Michael Foster
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Dries Vincent
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

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