Inflammatory Responses in Normal Volunteers and Patients With Abnormal Immune Responses

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Nov 3, 1999

Keywords

ClinConnect Summary

Patients with abnormal regulation of inflammation and with host defense defects often have an exaggerated or depressed inflammatory response with resultant difficulty in healing of recurrent infections. Delayed healing can be manifested by either a delay in wound healing, granuloma formation along the incision line, or dehiscence of a partially healed wound without evidence of infection. We are interested in studying the dynamics of host immune defenses during an experimentally induced inflammatory response using a well-studied suction blister device. This protocol is designed to study medi...

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ALL

Eligibility criteria

• * INCLUSION CRITERIA - PATIENTS:
• • Patients having or thought to have an immune defect between the ages of 6 and 65 years (inclusive) are eligible to participate.
• INCLUSION CRITERIA - NORMAL VOLUNTEERS:
• • Be a healthy adult of either sex and between the ages of 18 and 65 years old.
• • Weight greater than 110 pounds.
• • Not have any heart, lung, or kidney disease, or bleeding disorders.
• • Not have a history of viral hepatitis (B or C) since age 11.
• • Not have a history of intravenous injection drug use.
• • Not have a history of engaging in high-risk activities for exposure to the AIDS virus.
• • Not be pregnant.
• EXCLUSION CRITERIA - PATIENTS:
• • Patients less than 6 or greater than 65 years of age.
• EXCLUSION CRITERIA - NORMAL VOLUNTEER:
• • Less than 18 years old or older than 65 years.
• • Have viral hepatitis (B or C).
• • HIV positive.
• • Receiving chemotherapeutic agent(s), or have underlying malignancy.
• • Pregnant.
• • Have history of heart, lung, kidney disease, or bleeding disorders.