Search / Trial NCT00001310

Tissue Studies of Human Eye Diseases

Launched by NATIONAL EYE INSTITUTE (NEI) · Nov 3, 1999

Trial Information

Current as of December 08, 2024

Terminated

Keywords

Retinal Disease Diabetic Retinopathy Uveitis Age Related Macular Degeneration Corneal Disease Ocular Disease

ClinConnect Summary

The purpose of this project is to diagnose and evaluate ocular and related tissues with various diseases such as conjunctival, corneal, uveal, vitreoretinal, scleral, optic nerve, and orbital disorders, ocular degenerative, inflammatory, metabolic or genetic diseases, and tumors. These will be studied using light microscopy, electron microscopy, confocal microscopy, immunohistochemistry, molecular pathology including microdissection and polymerase chain reaction and in situ hybridization, ELISA, as well as measuring the functions of cellular organelles, e.g., mitochondrial function. Lymphoc...

Gender

ALL

Eligibility criteria

  • * INCLUSION CRITERIA:
  • Up to 5,000 subjects will be enrolled in the study at all sites combined. Subjects will be enrolled at NEI.
  • 1. Participants must be undergoing an eye procedure for clinical care of their condition which requires the removal of tissue specimens or have agreed pre-mortem to donate their eyes after death for research purposes.
  • 2. Participants must agree to the de-identified storage of their sample for potential use in future research projects.
  • 3. For conditions where blood is needed for analysis, participants must consent to having blood drawn for research evaluation, and be able to safely give a blood sample.
  • 4. Participants must be able to give informed consent for themselves and/or their minor children who wish to enroll.
  • EXCLUSION CRITERIA:
  • 1. Participant is unwilling or unable to give informed consent.

Trial Officials

Robert B Nussenblatt, M.D.

Principal Investigator

National Eye Institute (NEI)

About National Eye Institute (Nei)

The National Eye Institute (NEI), part of the U.S. National Institutes of Health (NIH), is dedicated to conducting and supporting innovative research to understand, prevent, and treat eye diseases and vision disorders. As a leading sponsor of clinical trials, NEI aims to advance knowledge in ocular health through rigorous scientific inquiry and collaboration with researchers, healthcare professionals, and institutions. By fostering the development of new therapies and technologies, NEI plays a pivotal role in enhancing the quality of life for individuals affected by visual impairments and eye conditions.

Locations

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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