Tissue Studies of Human Eye Diseases

Launched by NATIONAL EYE INSTITUTE (NEI) · Nov 3, 1999

Keywords

ClinConnect Summary

The purpose of this project is to diagnose and evaluate ocular and related tissues with various diseases such as conjunctival, corneal, uveal, vitreoretinal, scleral, optic nerve, and orbital disorders, ocular degenerative, inflammatory, metabolic or genetic diseases, and tumors. These will be studied using light microscopy, electron microscopy, confocal microscopy, immunohistochemistry, molecular pathology including microdissection and polymerase chain reaction and in situ hybridization, ELISA, as well as measuring the functions of cellular organelles, e.g., mitochondrial function. Lymphoc...

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • Up to 5,000 subjects will be enrolled in the study at all sites combined. Subjects will be enrolled at NEI.
• • 1. Participants must be undergoing an eye procedure for clinical care of their condition which requires the removal of tissue specimens or have agreed pre-mortem to donate their eyes after death for research purposes.
• • 2. Participants must agree to the de-identified storage of their sample for potential use in future research projects.
• • 3. For conditions where blood is needed for analysis, participants must consent to having blood drawn for research evaluation, and be able to safely give a blood sample.
• • 4. Participants must be able to give informed consent for themselves and/or their minor children who wish to enroll.
• EXCLUSION CRITERIA:
• • 1. Participant is unwilling or unable to give informed consent.