Search / Trial NCT00001327

Establishing the Physiology of Syringomyelia

Launched by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (NINDS) · Nov 3, 1999

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Trial Information

Current as of July 14, 2024

Completed

Keywords

Syringomyelia Chiari Malformation Magnetic Resonance Imaging Intraoperative Ultrasonography Hydrocephalus Spinal Cord Ventriculostomy Lumbar Puncture Pressure Measurement

Description

The purpose of this study is to establish the mechanism of development and progression of syringomyelia. Although syringomyelia usually accompanies anatomic abnormalities at the craniocervical junction, the pathophysiology that relates these anatomic abnormalities to syringomyelia development and progression is controversial. We have been testing the hypothesis that progression of syringomyelia associated with the Chiari I malformation is produced by the cerebellar tonsils partially occluding the subarachnoid space at the foramen magnum and acting as a piston on the partially enclosed spina...

Gender

All

Eligibility criteria

  • INCLUSION CRITERIA:
  • To be eligible to participate in this research study, the subject must:
  • Be 18 years of age or older.
  • Have syringomyelia.
  • Have a lesion that narrows the space for spinal fluid at the base of the skull or neck. Prior surgery for syringomyelia does not result in exclusion from the study if there is radiographic evidence of a syrinx and there is evidence of neurological deterioration related to the syrinx.
  • Be able to give informed consent.
  • EXCLUSION CRITERIA:
  • The subject will not be eligible to participate in this research study if the subject:
  • Is pregnant (because X-rays might injure a fetus).
  • Cannot have an MRI scan as determined by the radiologist.
  • Has a problem with bleeding that cannot be corrected.
  • Is unable to understand the risks of the testing and surgical therapy.
  • Has a blood test for HIV (the virus that causes AIDS) that is positive, because a positive HIV test would increase the risk of infection from research testing.

Attachments

readout_NCT00001327_2024-07-14.pdf

4.5 MB

NCT00001327_study_protocol.pdf

4.5 MB

About company

The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.

Contacts

JC

Jennifer Cobb

Immunology at National Institute of Allergy and Infectious Diseases (NIAID)

Locations

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Reviews (48)

4.6

All reviews come from applied patients

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Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Michael Foster
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Dries Vincent
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

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