The Effects of Hormones in Growth Hormone-Treated Girls With Turner Syndrome
Launched by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT (NICHD) · Nov 3, 1999
Current as of November 28, 2023
Turner syndrome is associated with short stature, multiple physical stigmata, and absent pubertal development. We propose to: (1) examine the effects of sex steroids (androgen) on multiple variables (growth rate, GH binding protein, IGF-I, and cognitive function), in the setting of supplemental growth hormone administration and (2) to investigate any synergistic or additive effects of the androgen and estrogen combination on the above variables.
- INCLUSION CRITERIA:
- Girls with Turner syndrome will qualify to participate in this study if they meet the following criteria:
- Karyotype diagnosis compatible with Turner syndrome.
- No treatment with estrogen, androgen or growth hormone exceeding twelve months, and no treatment with either of these agents in the preceding 3 months.
- Chronological age of 10.0 to 14.9 years.
- Bone age less than or equal to 12 years.
- EXCLUSION CRITERIA:
- Prior treatment with estrogen, androgen, or growth hormone for more than twelve months.
- Y component in peripheral karyotype.
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Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
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Philadelphia, Pennsylvania, United States
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