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The Effects of Hormones in Growth Hormone-Treated Girls With Turner Syndrome

Launched by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT (NICHD) · Nov 3, 1999

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Trial Information

Current as of March 16, 2025

Completed

Keywords

Turner's Syndrome Short Stature Cognitive Function Sex Steroids Turner Syndrome Ts

ClinConnect Summary

Turner syndrome is associated with short stature, multiple physical stigmata, and absent pubertal development. We propose to: (1) examine the effects of sex steroids (androgen) on multiple variables (growth rate, GH binding protein, IGF-I, and cognitive function), in the setting of supplemental growth hormone administration and (2) to investigate any synergistic or additive effects of the androgen and estrogen combination on the above variables.

Gender

FEMALE

Eligibility criteria

  • * INCLUSION CRITERIA:
  • Girls with Turner syndrome will qualify to participate in this study if they meet the following criteria:
  • • Karyotype diagnosis compatible with Turner syndrome.
  • • No treatment with estrogen, androgen or growth hormone exceeding twelve months, and no treatment with either of these agents in the preceding 3 months.
  • • Chronological age of 10.0 to 14.9 years.
  • • Bone age less than or equal to 12 years.
  • EXCLUSION CRITERIA:
  • • Prior treatment with estrogen, androgen, or growth hormone for more than twelve months.
  • • Y component in peripheral karyotype.

About Eunice Kennedy Shriver National Institute Of Child Health And Human Development (Nichd)

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) is a prominent research agency within the National Institutes of Health (NIH), dedicated to advancing the health and well-being of children, families, and individuals across the lifespan. NICHD supports a wide range of clinical trials and research initiatives aimed at understanding the complex biological, behavioral, and environmental factors that influence human development and health. By fostering innovative research and facilitating collaboration among scientists, healthcare professionals, and communities, NICHD plays a vital role in translating scientific discoveries into effective interventions and policies that enhance child health, reproductive health, and the prevention of diseases.

Locations

Bethesda, Maryland, United States

Philadelphia, Pennsylvania, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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