Natural History and Results of Dual Chamber (DDD) Pacemaker Therapy of Children With Obstructive Hypertrophic Cardiomyop...

Launched by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI) · Nov 3, 1999

Keywords

ClinConnect Summary

Several studies have shown that dual chamber (DDD) pacemaker therapy relieves LV outflow obstruction and improves symptoms in most adult patients with obstructive hypertrophic cardiomyopathy (HCM). It is however, uncertain whether DDD pacing will be efficacious in children with obstructive HCM, because of evolving cardiac morphology and increased LV hypertrophy and outflow obstruction associated with rapid body growth. We propose to monitor clinical progress, and cardiac morphologic and hemodynamic changes over several years following implantation of a DDD pacemaker in children who present ...

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Eligibility criteria

• • INCLUSION CRITERIA: DDD Pacemaker Therapy
• • Children of either gender, aged 5 to 15 years.
• • Presence of LV hypertrophy and LV outflow obstruction.
• • EXCLUSION CRITERIA: DDD Pacemaker Therapy
• • Other systemic disease that prevent evaluation by echocardiography or cardiac catheterization.
• • Chronic atrial fibrillation.
• • Positive pregnancy test.
• • INCLUSION CRITERIA: Cohort Study
• • Children of either gender, 5 to 20 years (children greater than 15 years will be included if there is access to reliable previous catheterization data).
• • Presence of LV hypertrophy and LV obstruction.
• • EXCLUSION CRITERIA: Cohort Study
• • Other systemic disease that prevent evaluation by echocardiography or cardiac catheterization.
• • Chronic atrial fibrillation.
• • Positive pregnancy test.