Analysis of Heart Muscle Function in Patients With Heart Disease and Normal Volunteers

Launched by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI) · Dec 9, 2002

Keywords

ClinConnect Summary

We propose to assess regional myocardial function using gated blood pool imaging acquired by a tomographic technique at rest and during stress in patients with myocardial ischemia (coronary artery disease, hypertrophic cardiomyopathy and microvascular angina). Gender differences in response to exercise and pharmacologic stress will also be evaluated. Normal subjects will be studied in order to establish a control database. Current methods of gated blood pool studies use planar imaging, with its attendant limitations; poor resolution and inadequate separation of the myocardial segments, only...

Gender

ALL

Eligibility criteria

• • Patients with known coronary artery disease (obstruction of greater than or equal to 50% in at least one major coronary artery).
• • Patients with hypertrophic cardiomyopathy.
• • Patients with microvascular angina.
• • No unstable angina.
• • No hepatic or renal failure.
• • Infective endocarditis
• • No primary valvular disease.
• • No congenital heart disease.
• • No pregnant or breast feeding women.