Search / Trial NCT00001485

Effects of Season on Melatonin Secretion in Healthy Men and Women and Patients With Seasonal Affective Disorder

Launched by NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH) · Dec 9, 2002

Apply for Trial

Trial Information

Current as of December 10, 2023

Completed

Keywords

Chemical Mediators Circadian Rhythms Gender Differences Melatonin Photoperiodism Seasonal Changes

Description

Changes in the duration of nocturnal melatonin secretion that are induced by seasonal changes in the length of the night trigger many of the dramatic seasonal changes in behavior that occur in animals. It has been hypothesized that melatonin plays a similar role as chemical mediator of the effects of season on mood in patients with seasonal affective disorder (SAD). For such a hypothesis to be tenable, it would be necessary to show that duration of nocturnal melatonin secretion changes on a seasonal basis in patients with SAD. We have preliminary evidence that the duration (and amplitude) o...

Gender

All

Eligibility criteria

  • Normal volunteers must be free of psychiatric illnesses.
  • Patients must meet the criteria of Rosenthal et al. for the diagnosis of SAD, as determined by a DSM IV diagnostic interview, and must be free of other major psychiatric illnesses.
  • All subjects must be free of major medical illnesses and must not be taking medications on a regular basis.
  • Patients must not test positive for antibodies to the AIDS virus.

Attachments

readout_NCT00001485_2023-12-10.pdf

4.5 MB

NCT00001485_study_protocol.pdf

4.5 MB

About company

The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.

Contacts

JC

Jennifer Cobb

Immunology at National Institute of Allergy and Infectious Diseases (NIAID)

Locations

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Reviews (48)

4.6

All reviews come from applied patients

5 stars
41
4 stars
6
3 stars
2
2 stars
0
1 stars
0
Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Michael Foster
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Dries Vincent
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Discussion 0