Analysis of Heart Muscle Function Following Exercise in Patients With Heart Disease
Launched by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI) · Dec 9, 2002
Trial Information
Current as of March 18, 2025
Completed
Keywords
ClinConnect Summary
Exercise-induced left ventricular regional wall motion abnormalities among patients with coronary artery disease indicate myocardial ischemia due to significant coronary artery narrowing. Recovery of such stress-induced wall motion abnormalities is thought to occur within minutes after the termination of exercise. However, in some patients, persistent contractile dysfunction has been observed up to 90 minutes into recovery. Whether persistent regional wall motion abnormalities after exercise are due to stunned myocardium (prolonged but reversible postischemic dysfunction despite restoration...
Gender
ALL
Eligibility criteria
- • Adult patients with greater than 50% stenosis in at least one major coronary artery.
- • No significant valvular heart disease.
- • No congenital heart disease.
- • No myocardial disease unrelated to co-existing coronary artery disease.
- • No severe angina where withdrawal of therapy would be dangerous.
- • No recent unstable angina or myocardial infarction (less than 1 month).
- • Not pregnant or breast feeding.
- • No history of ventricular tachycardia or malignant arrhythmias.
- • No history of active bronchospastic disease.
About National Heart, Lung, And Blood Institute (Nhlbi)
The National Heart, Lung, and Blood Institute (NHLBI) is a leading component of the National Institutes of Health (NIH), dedicated to advancing research and clinical trials focused on cardiovascular, pulmonary, and hematologic diseases. With a mission to improve public health through innovative research, the NHLBI supports a wide range of studies aimed at understanding, preventing, and treating heart and lung conditions. By collaborating with academic institutions, healthcare providers, and patient communities, the NHLBI strives to translate scientific discoveries into effective clinical practices, ultimately enhancing the quality of life for individuals affected by these critical health issues.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Bethesda, Maryland, United States
People applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0
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