Search / Trial NCT00001543

Dynamics of Leptin and Endocrine Function

Launched by NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH) · Nov 3, 1999

Trial Information

Current as of December 14, 2024

Completed

Keywords

Major Depression Metabolic Clearance Rate Pulsatility Adrenocorticotropic Hormone Cortisol Corticotropin Releasing Hormone Binding Protein Pharmacokinetics Half Life Bioavailability Cushing's Syndrome

ClinConnect Summary

Our group has tested the hypothesis that the molecules involved in the neurobiology of the stress response are key elements in the pathophysiology, treatment, and medical consequences of major depressive disorder. Leptin is implicated in the regulation of adipose tissue, body weight and homeostasis. In the first three years of this protocol we accomplished the following: (1) discovered leptin pulsatility; (2) showed that is secreted in a highly organized manner in men and women; (3) showed for the first time in humans an inverse relation between rapid fluctuations in plasma leptin concentra...

Gender

ALL

Eligibility criteria

  • Depressed patients must have a history of past major depression of at least four months duration, or a history of two or more briefer episodes. Must be overweight.
  • Must not need a hospital admission as part of their treatment.
  • Overweight normal volunteers.
  • No subjects on chronic medication which cannot be washed out for one month.
  • No subjects with any serious medical illness.
  • No women who are pregnant, trying to become pregnant, or sexually active and not using effective contraception.
  • No patients with HIV infection.
  • No subjects who cannot discontinue use of alcohol/tobacco.

About National Institute Of Mental Health (Nimh)

The National Institute of Mental Health (NIMH) is a leading federal agency dedicated to advancing the understanding and treatment of mental health disorders through innovative research and clinical trials. As part of the National Institutes of Health (NIH), NIMH focuses on a broad spectrum of mental health issues, including mood disorders, anxiety disorders, schizophrenia, and developmental disorders. By fostering collaboration among researchers, clinicians, and the community, NIMH aims to translate scientific discoveries into effective interventions and improve mental health outcomes for individuals across the lifespan. Through its commitment to rigorous research methodologies and ethical standards, NIMH plays a pivotal role in shaping the future of mental health care and policy.

Locations

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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