Genetics of Obsessive-Compulsive Disorder

Launched by NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH) · Nov 3, 1999

Keywords

ClinConnect Summary

Obsessive-compulsive disorder (OCD) is a severe, heritable condition with a lifetime prevalence of about two percent of the population. The mode of inheritance is poorly understood but is likely complex, involving multiple loci of small to major effect. Since 1995, the NIMH-IRP has been active in a multi-center family study of OCD, led by Dr. Gerald Nestadt of Johns Hopkins University, which was approved via a competitive NIMH extramural application (MH 502140). An expanded consortium of sites (including new sites at Brown and Harvard Universities) anticipates adding 300 new affected sib-pa...

Gender

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Eligibility criteria

• * INCLUSION CRITERIA:
• • Must have a diagnosis of obsessive-compulsive disorder, or be a family member (usually a parent or sibling) of someone with obsessive-compulsive disorder.
• • Certain disorders are considered part of OCD "spectrum" disorders and often include family members with OCD. These include Tourette's Syndrome, other individuals with tics, and Trichotillomania (severe hair pulling), and other forms of repetitive behaviors.
• • Persons with primary behavioral difficulties who do not fit with the current definitions of "OCD and OCD spectrum disorders" may not be eligible. These include compulsive shopping, gambling, or compulsive sexual behaviors.