Search / Trial NCT00001572

Vaccination of Follicular Lymphomas With Tumor-Derived Immunoglobulin Idiotype

Launched by NATIONAL CANCER INSTITUTE (NCI) · Nov 3, 1999

Trial Information

Current as of December 08, 2024

Completed

Keywords

B Cell Lymphoma Bcl 2 Positive Tumor Immunization Induction Chemotherapy Lymphoma Vaccine Follicular Lymphoma Tumor Derived Immunoglobulin Idiotype

ClinConnect Summary

The idiotype of the immunoglobulin on a given B cell malignancy (Id) can serve as a clonal marker, and a previous pilot study in lymphoma patients has demonstrated that autologous Id protein can be formulated into an immunogenic, tumor specific antigen by conjugation to a carrier protein (KLH) and administration with an emulsion-based adjuvant.

The objectives of this study are: 1) to evaluate feasibility and toxicity of new vaccine formulations, and 2) to evaluate cellular and humoral immune responses against the unique idiotype of the patient's lymphoma.

The goal of this study is to trea...

Gender

ALL

Eligibility criteria

  • * INCLUSION CRITERIA:
  • Sample size: up to 30 patients.
  • Sex distribution: Male and female.
  • Age: Patients must be greater than or equal to 18 years old.
  • Patients must meet all of the following eligibility criteria:
  • Tissue diagnosis of: follicular small cleaved cell or follicular mixed lymphoma with surface IgM, IgA, or IgG phenotype with a monoclonal heavy and light chain. Pathology slides must be submitted to the NIH Pathology Department for review.
  • Stage III or IV lymphoma.
  • A single peripheral lymph node of at least 2x2 to 3x3 cm size and accessible for biopsy/harvest.
  • Karnofsky status greater than or equal to 70%.
  • Life expectancy of greater than 1 year.
  • Serum creatinine less than or equal to 1.5 mg/dl unless felt to be secondary to lymphoma.
  • Bilirubin less than or equal to 1.5 mg/dl unless felt to be secondary to lymphoma or Gilbert's disease. SGOT/SGPT less than or equal to 3.5 x upper limit of normal.
  • Ability to give informed consent. Ability to return to clinic for adequate follow-up for the period that the protocol requires.
  • There are no gender or racial / ethnic restrictions on patient selection. This protocol is open to all genders and racial / ethnic groups.
  • EXCLUSION CRITERIA:
  • The presence of any exclusion criteria (listed below) will prohibit entry onto study:
  • Prior total body irradiation.
  • Presence of antibodies to HIV or hepatitis B surface antigen or other active infectious process.
  • Pregnant or lactation. Fertile men and women must plan to use an effective contraception. A beta-HCG level will be obtained in women of child-bearing potential.
  • Patients with previous or concomitant malignancy, regardless of site, except curatively treated squamous or basal cell carcinoma of the skin, or effectively treated carcinoma in situ of the cervix.
  • Patient unwilling to give informed consent.
  • Failure to meet any of the eligibility criteria in Section 3.2.
  • Any medical or psychiatric condition that in the opinion of the protocol chairman would compromise the patient's ability to tolerate this treatment.
  • Patients with CNS lymphoma (current or previously treated) will not be eligible.

About National Cancer Institute (Nci)

The National Cancer Institute (NCI) is a prominent component of the National Institutes of Health (NIH), dedicated to advancing cancer research and improving patient outcomes through innovative clinical trials. As a leading sponsor of cancer-related studies, NCI focuses on facilitating the development of new therapies, enhancing prevention strategies, and understanding the biology of cancer. The institute collaborates with academic institutions, healthcare providers, and industry partners to conduct rigorous clinical trials that aim to translate scientific discoveries into effective treatments. NCI’s commitment to fostering a robust research environment supports the mission to eliminate cancer as a major health problem.

Locations

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

Similar Trials